7alpha-Hydroxypregnenolone

Base Information

Chemical Name:7alpha-Hydroxypregnenolone
CAS No.:30626-96-1
Molecular Formula:C21H32O3
Molecular Weight:332.483
Hs Code.:
DSSTox Substance ID:DTXSID10433466
Nikkaji Number:J704.244B
Wikidata:Q27155398
Mol file:30626-96-1.mol

Synonyms:7-hydroxypregnenolone;7alpha-hydroxypregnenolone

Suppliers and Price of 7alpha-Hydroxypregnenolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7α-HydroxyPregnenolone
25mg
$ 1320.00

Medical Isotopes, Inc.
7α-HydroxyPregnenolone
25 mg
$ 2200.00

Total 4 raw suppliers

Chemical Property of 7alpha-Hydroxypregnenolone

Chemical Property:

Melting Point:190 °C
Boiling Point:486.1±45.0 °C(Predicted)
PKA:13.99±0.70(Predicted)
PSA：57.53000
Density:1.15±0.1 g/cm3(Predicted)
LogP:3.48610
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:332.23514488
Heavy Atom Count:24
Complexity:582

Purity/Quality:

99% ^*data from raw suppliers

7α-HydroxyPregnenolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C
Description 7α-Hydroxypregnenolone is a neuroactive metabolite of pregnenolone. It acts as an important neuromodulator to increase locomotor activity.
Biological functions Dopamine neurons are located in the medial brain region, specifically in the TA and posterior tuberal nucleus; they project to the rostral brain region including the striatum.7α-Hydroxypregnenolone increases the concentration of dopamine in the telencephalic region?including the striatum,which is known to be involved in the regulation of locomotor behavior in vertebrates. Thus, there is potential for the direct regulation of dopamine release by the action of 7α-hydroxypregnenolone synthesized in the TA. Acute stress increases the synthesis of 7α-hydroxypregnenolone through corticosterone action in newts.7α-Hydroxypregnenolone increases serotonin concentrations in the diencephalon including the DMH under stress.The pineal gland, an endocrine organ located close to the brain, is an important site of production of neurosteroids de novo from cholesterol in birds.7α-Hydroxypregnenolone is a major pineal neurosteroid that stimulates locomotor activity in juvenile chickens, connecting light-induced gene expression with locomotion.
Uses 7α-Hydroxy Pregnenolone is a hydroxylated metabolite of Pregnenolone (P712200).

Technology Process of 7alpha-Hydroxypregnenolone

There total 5 articles about 7alpha-Hydroxypregnenolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: