4-ACETOXY-4'-BROMOBENZOPHENONE

Base Information

• Chemical Name: 4-ACETOXY-4'-BROMOBENZOPHENONE
• CAS No.: 4306-46-1
• Molecular Formula: C15H11BrO3
• Molecular Weight: 319.155
• Hs Code.: 2915390090
• Mol file: 4306-46-1.mol

Synonyms:4-ACETOXY-4'-BROMOBENZOPHENONE

Chemical Property of 4-ACETOXY-4'-BROMOBENZOPHENONE

Chemical Property:

• Vapor Pressure: 2.49E-07mmHg at 25°C
• Boiling Point: 422°C at 760 mmHg
• Flash Point: 209°C
• PSA: 43.37000
• Density: 1.441g/cm³
• LogP: 3.60540

Purity/Quality:

95% ^*data from raw suppliers

4-Acetoxy-4'-bromobenzophenone >90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETOXY-4'-BROMOBENZOPHENONE

There total 4 articles about 4-ACETOXY-4'-BROMOBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

monomethyl oxalyl chloride (5781-53-3) + 4-hydroxyphenyl-(4-bromo-phenyl)-methanone (4369-50-0) + acetyl chloride (75-36-5) → 4-Brom-4'-acetoxy-benzophenon (4306-46-1)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1002/1526-4998(200102)57:2<191::AID-PS275>3.0.CO;2-O

Reference yield:

4-bromo-4'-methoxybenzophenone (54118-75-1) → 4-Brom-4'-acetoxy-benzophenon (4306-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / pyridine / CH₂Cl₂ / 16 h / 0 - 20 °C

With pyridine; In dichloromethane;

DOI:10.1002/1526-4998(200102)57:2<191::AID-PS275>3.0.CO;2-O

Reference yield:

methoxybenzene (100-66-3) → 4-Brom-4'-acetoxy-benzophenon (4306-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: AlCl₃ / 1,2-dichloro-ethane

1.2: 1,2-dichloro-ethane

2.1: 73 percent / pyridine / CH₂Cl₂ / 16 h / 0 - 20 °C

With pyridine; aluminium trichloride; In dichloromethane; 1,2-dichloro-ethane; 1.1: Friedel-Crafts reaction;

DOI:10.1002/1526-4998(200102)57:2<191::AID-PS275>3.0.CO;2-O

upstream raw materials:

monomethyl oxalyl chloride

4-hydroxyphenyl-(4-bromo-phenyl)-methanone

acetyl chloride

4-bromo-4'-methoxybenzophenone

Downstream raw materials:

acetic acid 4-[4-(3-hydroxy-3-methyl-but-1-ynyl)-benzoyl]-phenyl ester

Refernces