Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI)

Base Information

• Chemical Name: Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI)
• CAS No.: 494862-24-7
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Mol file: 494862-24-7.mol

Synonyms:Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI)

Chemical Property of Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Fluorophenyl)propanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI)

There total 6 articles about Benzeneacetaldehyde, 3-fluoro-alpha-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbon monoxide (201230-82-2) + 3-fluorostyrene (350-51-6) → 2-(3'-fluorophenyl)propanal (494862-24-7) + 3-(3-fluorophenyl)propanal (245070-85-3)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium 4-dodecylbenzenesulfonate; Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate; In water; toluene; at 60 ℃; under 30003 Torr;

DOI:10.1016/j.cclet.2021.07.068

Reference yield: 68.0%

carbon monoxide (201230-82-2) + 3-fluorostyrene (350-51-6) → 2-(3'-fluorophenyl)propanal (494862-24-7)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; hydrogen; copper(l) cyanide; sodium t-butanolate; In toluene; at 100 ℃; for 20h; under 22502.3 Torr; regioselective reaction;

DOI:10.1039/d1sc05474k

Reference yield:

carbon monoxide (201230-82-2) + 1-ethynyl-3-fluoro-benzene (2561-17-3) → 2-(3'-fluorophenyl)propanal (494862-24-7) + 3-(3-fluorophenyl)propanal (245070-85-3) + 3-fluorostyrene (350-51-6) + 3-fluorocinnamaldehyde (56578-38-2,42291-83-8)

Guidance literature:

With dicarbonyl(acetylacotonato)rhodium(I); hydrogen; 2,2'-bis((bis(5-methoxy-1H-indol-1-yl)phosphaneyl)oxy)-1,1'-biphenyl; In toluene; cyclohexanol; at 30 ℃; for 8h; under 3000.3 Torr; Autoclave;

DOI:10.1021/acs.orglett.1c02140

upstream raw materials:

1-(3-fluorophenyl)ethanone

C₁₀H₁₁FO

carbon monoxide

1-ethynyl-3-fluoro-benzene

Downstream raw materials:

(R)?diethyl 2?(2?(3?fluorophenyl)propylidene)malonate

diethyl (R)-1-(2-(3'-fluorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate

N-(2-(3'-fluorophenyl)-1-oxopropan-2-yl)-4-methylbenzenesulfonamide

Refernces

• 1、 Chen, Fen-Er,Gao, Peng,Ke, Miaolin,Liang, Guanfeng,Ru, Tong. "Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst". . . Retrieved 2021/08/26.
• 2、 List, Benjamin,Coric, Ilija,Grygorenko, Oleksandr O.,Kaib, Philip S. J.,Komarov, Igor,Lee, Anna,Leutzsch, Markus,Chandra Pan, Subhas,Tymtsunik, Andrey V.,Van Gemmeren, Manuel. "The catalytic asymmetric α-benzylation of aldehydes". . p. 282 - 285. Retrieved 2014/01/17.