9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-

Base Information

Chemical Name:9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-
CAS No.:1200130-75-1
Molecular Formula:C17H9BrN4O3S
Molecular Weight:429.253
Hs Code.:
Mol file:1200130-75-1.mol

Synonyms:9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-;3-Bromo-5-hydroxy-9-(phenylsulfonyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile

Suppliers and Price of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-

Chemical Property:

Purity/Quality:: 98%Min ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)-

There total 10 articles about 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-broMo-5-hydroxy-9-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1200130-74-0
1-benzenesulfonyl-5-bromo-2-{[cyanomethyl-(toluene-4-sulfonyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

: 1200130-75-1
9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: 1-benzenesulfonyl-5-bromo-2-{[cyanomethyl-(toluene-4-sulfonyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 10 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1200130-75-1
9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; potassium iodate / 100 °C

1.2: 1.5 h

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C

4.1: aluminum (III) chloride / dichloromethane / 0.83 h

4.2: 18 h

5.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 1.33 h / 0 - 20 °C

6.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / 1,2-dichloro-ethane / 1.5 h / Reflux

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

8.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 10 °C

With potassium iodate; N-Bromosuccinimide; sulfuric acid; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; 1,1'-azobis(1-cyanocyclohexanenitrile); aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 381233-96-1
2-amino-3-iodo-5-bromopyridine

: 1200130-75-1
9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C

3.1: aluminum (III) chloride / dichloromethane / 0.83 h

3.2: 18 h

4.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 1.33 h / 0 - 20 °C

5.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / 1,2-dichloro-ethane / 1.5 h / Reflux

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 10 °C

With N-Bromosuccinimide; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; 1,1'-azobis(1-cyanocyclohexanenitrile); aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;