9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)-

Base Information

Chemical Name:9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)-
CAS No.:1200130-70-6
Molecular Formula:C₁₇H₁₀N₄O₃S
Molecular Weight:350.357
Hs Code.:
Mol file:1200130-70-6.mol

Synonyms:9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Suppliers and Price of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)-

Chemical Property:

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Technology Process of 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)-

There total 12 articles about 9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 5-hydroxy-9-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1200130-69-3
1-benzenesulfonyl-2-((cyanomethyl(toluene-4-sulfonyl)amin)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

: 1200130-70-6
9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: 1-benzenesulfonyl-2-((cyanomethyl(toluene-4-sulfonyl)amin)methyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 89.0%

: 1200130-75-1
9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

: 1200130-70-6
9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 381233-96-1
2-amino-3-iodo-5-bromopyridine

: 1200130-70-6
9-benzenesulfonyl-5-hydroxy-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C

3.1: aluminum (III) chloride / dichloromethane / 0.83 h

3.2: 18 h

4.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 1.33 h / 0 - 20 °C

5.1: N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile) / 1,2-dichloro-ethane / 1.5 h / Reflux

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 10 °C

8.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethyl acetate; N,N-dimethyl-formamide; ethanol / 16 h / 20 °C

With N-Bromosuccinimide; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium hydride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; 1,1'-azobis(1-cyanocyclohexanenitrile); aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;