GDC-0994

Base Information

Chemical Name:GDC-0994
CAS No.:1453848-26-4
Molecular Formula:C21H18ClFN6O2
Molecular Weight:440.864
Hs Code.:2933998090
Mol file:1453848-26-4.mol

Synonyms:GDC-0994;(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994;(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one;1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone

Suppliers and Price of GDC-0994

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
GDC-0994
2.5mg
$ 1105.00

DC Chemicals
Ravoxertinib(GDC0994) >98%,eepurity:94%
1 g
$ 3500.00

DC Chemicals
Ravoxertinib(GDC0994) >98%,eepurity:94%
100 mg
$ 1000.00

Crysdot
GDC-0994 98+%
50mg
$ 851.00

Crysdot
GDC-0994 98+%
10mg
$ 293.00

ChemScene
Ravoxertinib 99.75%
10mg
$ 120.00

ChemScene
Ravoxertinib 99.75%
5mg
$ 96.00

ChemScene
Ravoxertinib 99.75%
50mg
$ 360.00

Chemenu
(S)-1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-5-pyrazolyl)amino]-4-pyrimidyl]-2(1H)-pyridone 98%
50mg
$ 491.00

Cayman Chemical
GDC-0994 ≥98%
10mg
$ 350.00

Total 34 raw suppliers

Chemical Property of GDC-0994

Chemical Property:

Boiling Point:734.6±70.0 °C(Predicted)
PKA:14.03±0.10(Predicted)
PSA：97.86000
Density:1.45±0.1 g/cm3(Predicted)
LogP:3.22960
Solubility.:≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

GDC-0994 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.
Uses GDC-0994 is a potent and orally available ERK12 inhibitor shown to prevent ERK-dependant tumor cell proliferation and survival.

Technology Process of GDC-0994

There total 13 articles about GDC-0994 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453851-69-8
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)-pyridin-2(1H)-one

: 1453848-26-4
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride / water; ethyl acetate / 0.25 h / 20 °C

With hydrogenchloride; sodium hydride; In water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1453851-79-0
(S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453848-26-4
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3: hydrogenchloride / water; ethyl acetate / 0.25 h / 20 °C

With hydrogenchloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1453854-84-6
(R)-1-(4-chloro-3-fluorophenyl)ethane-1,2-diol

: 1453848-26-4
(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.17 h / 0 °C

3.2: 30 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C

5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride / water; ethyl acetate / 0.25 h / 20 °C

With 1H-imidazole; hydrogenchloride; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;