MI-773

Base Information

Chemical Name:MI-773
CAS No.:1303607-07-9
Molecular Formula:C29H34Cl2FN3O3
Molecular Weight:562.512
Hs Code.:
Mol file:1303607-07-9.mol

Synonyms:MI-773;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide

Suppliers and Price of MI-773

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MI-773
100mg
$ 1525.00

Crysdot
MI-773 98+%
100mg
$ 1225.00

Crysdot
MI-773 98+%
5mg
$ 112.00

ChemScene
MI-773 98.05%
100mg
$ 1800.00

ChemScene
MI-773 98.05%
50mg
$ 972.00

ChemScene
MI-773 98.05%
10mg
$ 252.00

ChemScene
MI-773 98.05%
5mg
$ 156.00

Total 5 raw suppliers

Chemical Property of MI-773

Chemical Property:

Boiling Point:732.1±60.0 °C(Predicted)
PKA:12.03±0.70(Predicted)
PSA：90.46000
Density:1.36±0.1 g/cm3(Predicted)
LogP:6.16020

Purity/Quality:

98% ^*data from raw suppliers

MI-773 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses MI-773 is an inhibitor of MDM2-p53 protein-protein interaction (MDM2 inhibitors), currently investigated in clinical trials for cancer treatment.

Technology Process of MI-773

There total 5 articles about MI-773 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1303609-36-0
C₄₃H₄₆Cl₂FN₃O₄

: 1303607-07-9
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetone; acetonitrile; Cooling with ice;

Reference yield:

: 74444-81-8
5-chloro-1,3-dihydro-2H-inden-2-one

: 1303607-07-9
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / methanol / 3 h / 20 °C

2: toluene / Molecular sieve; Reflux

3: tetrahydrofuran / 48 h / 20 °C

4: ammonium cerium (IV) nitrate / water; acetone; acetonitrile / Cooling with ice

With piperidine; ammonium cerium (IV) nitrate; In tetrahydrofuran; methanol; water; acetone; toluene; acetonitrile;

Reference yield:

: 897365-76-3
(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one

: 1303607-07-9
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / Molecular sieve; Reflux

2: tetrahydrofuran / 48 h / 20 °C

3: ammonium cerium (IV) nitrate / water; acetone; acetonitrile / Cooling with ice

With ammonium cerium (IV) nitrate; In tetrahydrofuran; water; acetone; toluene; acetonitrile;