CLOBAZAM

Base Information Edit

Chemical Name:CLOBAZAM
CAS No.:22316-47-8
Molecular Formula:C16H13 Cl N2 O2
Molecular Weight:300.744
Hs Code.:
European Community (EC) Number:244-908-7
NSC Number:336279
UNII:2MRO291B4U
DSSTox Substance ID:DTXSID2046759
Nikkaji Number:J11.411A
Wikipedia:Clobazam
Wikidata:Q412164
NCI Thesaurus Code:C81615
RXCUI:21241
Pharos Ligand ID:41K8FDCNX4U7
Metabolomics Workbench ID:42725
ChEMBL ID:CHEMBL70418
Mol file:22316-47-8.mol

Synonyms:Clobazam;Clobazepam; Frisium; Frizium; H 4723; HR 376; LM 2717; Mystan; NSC 336279; Urbadan;Urbanyl

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of CLOBAZAM Edit

Chemical Property:

Vapor Pressure:1.82E-16mmHg at 25°C
Melting Point:162-164°C
Refractive Index:1.5200 (estimate)
Boiling Point:643.8°Cat760mmHg
PKA:8.59±0.20(Predicted)
Flash Point:343.2°C
PSA：40.62000
Density:1.335g/cm³
LogP:3.50120
Storage Temp.:2-8°C
Solubility.:Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in alcohol.
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:300.0665554
Heavy Atom Count:21
Complexity:423

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45-24/25-22-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Anticonvulsants
Canonical SMILES:CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Recent ClinicalTrials:The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children
Recent EU Clinical Trials:A phase 2, double-blind, randomized, placebo-controlled study to investigate possible drug-drug interactions between clobazam and cannabidiol (GWP42003-P)
Description Clobazam is a first-generation AED known under the proprietary brand name of Frisium? (Sanofi, Paris) in the UK and Onfi? (Lundbeck, Copenhagen) in the USA.
Indications Epilepsy: adjunctive therapy of focal and generalized seizures. Recommendations summarized from NICE (2012) Seizure types: adjunctive (generalized tonic- clonic seizures, focal seizures), on referral to tertiary care (absence seizures, myoclonic seizures). Epilepsy types: adjunctive (epilepsy with generalized tonic- clonic seizures only), on referral to tertiary care (absence syndromes, juvenile myoclonic epilepsy, idiopathic generalized epilepsy):? Psychiatry— short-term relief (2–4 weeks) of severe, disabling, or unacceptably distressing anxiety, occurring alone or in association with insomnia, or shortterm psychosomatic, organic, or psychotic illness (adjunctive treatment in patients with psychotic illness).
Uses Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. Controlled substance (depressant).
Therapeutic Function Tranquilizer
Clinical Use Benzodiazepine: Anticonvulsant Anxiolytic
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: increased sedative effects; serious adverse events reported with clozapine and benzodiazepines. Antivirals: concentration possibly increased by ritonavir. Disulfiram: metabolism of clobazam inhibited; increased sedative effects. Sodium oxybate: enhanced effects of sodium oxybate - avoid.

Technology Process of CLOBAZAM

There total 14 articles about CLOBAZAM which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%