1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN

Base Information

• Chemical Name: 1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN
• CAS No.: 174913-17-8
• Molecular Formula: C7H5BrCl2O
• Molecular Weight: 255.926
• Mol file: 174913-17-8.mol

Synonyms:1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN;1-bromo-2,5-dichloro-3-methoxybenzene

Chemical Property of 1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN

Chemical Property:

• PSA: 9.23000
• LogP: 3.76450

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-2,5-dichloro-3-methoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN

There total 2 articles about 1-BROMO-2,5-DICHLORO-3-METHOXYBENZEN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + 1-bromo-2,5-dichloro-3-fluorobenzene (202865-57-4) → 1-bromo-2,5-dichloro-3-methoxybenzene (174913-17-8)

Guidance literature:

methanol; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium tert-butylate; In toluene; at 80 ℃; for 0.416667h; Inert atmosphere;

1-bromo-2,5-dichloro-3-fluorobenzene; In toluene; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

1-bromo-2,5-dichloro-3-fluorobenzene (202865-57-4) + sodium methylate (124-41-4) → 1-bromo-2,5-dichloro-3-methoxybenzene (174913-17-8)

Guidance literature:

In methanol; for 16h; Heating / reflux;

Reference yield: 61.0%

1-bromo-2,5-dichloro-3-methoxybenzene (174913-17-8) + p-methoxybenzylmercaptan (6258-60-2) → 2,5-dichloro-1-methoxy-3-((4-methoxybenzyl)sulfanyl)benzene (1452478-83-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 90 ℃; for 4h; Inert atmosphere;

upstream raw materials:

1-bromo-2,5-dichloro-3-fluorobenzene

sodium methylate

methanol

Downstream raw materials:

2,5-dichloro-1-methoxy-3-((4-methoxybenzyl)sulfanyl)benzene

2,5-dichloro-3-methoxybenzenethiol

methyl 4-((2,5-dichloro-3-methoxyphenyl)sulfanyl)-3-oxobutanoate

Refernces

• 1、 -. "PYRIDINE DERIVATIVES". Page/Page column 153. . Retrieved 2009/01/20.