3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione

Base Information

Chemical Name:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione
CAS No.:1356935-80-2
Molecular Formula:C₁₇H₁₅F₆N₃O₂
Molecular Weight:407.315
Hs Code.:
Mol file:1356935-80-2.mol

Synonyms:3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione

Suppliers and Price of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Strem Chemicals
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(2S)-2-pyrrolidinylmethyl]amino]-3-cyclobutene-1,2-dione, 98% 98%
100mg
$ 109.00

Total 3 raw suppliers

Chemical Property of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione

Chemical Property:

Boiling Point:406.5±55.0 °C(Predicted)
PKA:10.48±0.10(Predicted)
PSA：70.23000
Density:1.49±0.1 g/cm3(Predicted)
LogP:3.63380

Purity/Quality:

99% ^*data from raw suppliers

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(2S)-2-pyrrolidinylmethyl]amino]-3-cyclobutene-1,2-dione, 98% 98% ^*data from reagent suppliers

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Technology Process of 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione

There total 2 articles about 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(2S)-2-pyrrolidinylMethyl]aMino]-3-Cyclobutene-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₃F₆N₃O₄

: 1356935-80-2
(S)-3-(3,5-bis(trifluoromethyl)phenylamino)-4-(pyrrolidin-2-ylmethylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1021/ja211878x

Reference yield:

: 1223105-85-8
3-(3,5-ditrifluoromethylphenylamino)-4-methoxybutane-3-en-1,2-dione

: 119020-01-8
(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1356935-80-2
(S)-3-(3,5-bis(trifluoromethyl)phenylamino)-4-(pyrrolidin-2-ylmethylamino)cyclobut-3-ene-1,2-dione

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 48 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

With trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/ja211878x