tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate
CAS No.:306298-26-0
Molecular Formula:C26H40F3N3O3
Molecular Weight:499.617
Hs Code.:
Mol file:306298-26-0.mol

Synonyms:tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate

Suppliers and Price of tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
TERT-BUTYL-4-((S)-4-((R)-2-METHOXY-1-(4-(TRIFLUOROMETHYL)PHENYL)ETHYL)-3-METHYLPIPERAZIN-1-YL)-4-METHYLPIPERIDINE-1-CARBOXYLATE 95.00%
5MG
$ 504.26

Total 3 raw suppliers

Chemical Property of tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate

Chemical Property:

PSA：45.25000
LogP:5.00230

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL-4-((S)-4-((R)-2-METHOXY-1-(4-(TRIFLUOROMETHYL)PHENYL)ETHYL)-3-METHYLPIPERAZIN-1-YL)-4-METHYLPIPERIDINE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate

There total 7 articles about tert-butyl 4-((S)-4-((R)-2-Methoxy-1-(4-(trifluoroMethyl)phenyl)ethyl)-3-Methylpiperazin-1-yl)-4-Methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-16-1
methylmagnesium bromide

: 745810-23-5
4-Cyano-4-{(S)-4-[(R)-2-methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester

: 306298-26-0
4-{(S)-4-[(R)-2-Methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1021/jm0304515

Reference yield:

: 26771-69-7
2-methoxy-1-(4-(trifluoromethyl)phenyl)ethan-1-one

: 306298-26-0
4-{(S)-4-[(R)-2-Methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane dimethylsulfide; (S)-2-methyl-CBS-oxaborolidine / 1 h

2.1: triethylamine / CH₂Cl₂ / 0.5 h / cooling

3.1: 14.8 g / K₂CO₃ / acetonitrile / 72 h / Heating

4.1: 7.9 g / trifluoroacetic acid / CH₂Cl₂ / 3 h / 20 °C

5.1: Ti(OiPr)4 / CH₂Cl₂ / 20 h / 20 °C

5.2: 13.4 g / CH₂Cl₂; toluene / 20 h

6.1: 76 percent / tetrahydrofuran / 48 h / 20 °C

With titanium(IV) isopropylate; dimethylsulfide borane complex; potassium carbonate; triethylamine; trifluoroacetic acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm0304515

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 306298-26-0
4-{(S)-4-[(R)-2-Methoxy-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazin-1-yl}-4-methyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ti(OiPr)4 / CH₂Cl₂ / 20 h / 20 °C

1.2: 13.4 g / CH₂Cl₂; toluene / 20 h

2.1: 76 percent / tetrahydrofuran / 48 h / 20 °C

With titanium(IV) isopropylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0304515