4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Base Information

Chemical Name:4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol
CAS No.:1364677-06-4
Molecular Formula:C₁₆H₁₆ClNO₂
Molecular Weight:289.762
Hs Code.:
Mol file:1364677-06-4.mol

Synonyms:4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Suppliers and Price of 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

There total 4 articles about 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1364677-04-2
6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

: 1364677-06-4
4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: With tetramethylammonium bromide; acetic acid; zinc; at 40 - 50 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm4010708

Reference yield:

: 6636-78-8
2-chloro-3-hydroxypyridine

: 1364677-06-4
4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water / 0.25 h / 90 °C / Inert atmosphere

1.2: 18 h / Inert atmosphere

2.1: sodium hydrogencarbonate / water / 0.25 h / Inert atmosphere

2.2: 18 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 4 h / 90 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene / 1.5 h / 90 °C / Inert atmosphere

5.1: acetic acid; tetramethylammonium bromide; zinc / 24 h / 40 - 50 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetramethylammonium bromide; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; zinc; In water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm4010708

Reference yield:

: 208519-41-9
2-chloro-6-(hydroxymethyl)-3-pyridinol

: 1364677-06-4
4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 0.25 h / Inert atmosphere

1.2: 18 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 90 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene / 1.5 h / 90 °C / Inert atmosphere

4.1: acetic acid; tetramethylammonium bromide; zinc / 24 h / 40 - 50 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetramethylammonium bromide; sodium hydride; sodium hydrogencarbonate; sodium carbonate; acetic acid; zinc; In water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm4010708