6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Base Information

Chemical Name:6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol
CAS No.:1364677-04-2
Molecular Formula:C₁₆H₁₅Cl₂NO₂
Molecular Weight:0
Hs Code.:
Mol file:1364677-04-2.mol

Synonyms:6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

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Chemical Property of 6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

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Technology Process of 6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

There total 4 articles about 6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1364677-02-0
[6-chloro-5-(cyclopropylmethoxy)-4-iodo-2-pyridyl]methanol

: 1679-18-1
4-Chlorophenylboronic acid

: 1364677-04-2
6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In toluene; at 90 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/jm4010708

Reference yield:

: 6636-78-8
2-chloro-3-hydroxypyridine

: 1364677-04-2
6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 0.25 h / 90 °C / Inert atmosphere

1.2: 18 h / Inert atmosphere

2.1: sodium hydrogencarbonate / water / 0.25 h / Inert atmosphere

2.2: 18 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 4 h / 90 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene / 1.5 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium hydrogencarbonate; sodium carbonate; In water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm4010708

Reference yield:

: 208519-41-9
2-chloro-6-(hydroxymethyl)-3-pyridinol

: 1364677-04-2
6-chloro-4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-2-pyridinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water / 0.25 h / Inert atmosphere

1.2: 18 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 4 h / 90 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene / 1.5 h / 90 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium hydrogencarbonate; sodium carbonate; In water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm4010708