2-(4-Nitro-2-ethoxyphenyl)pthaliMide

Base Information

• Chemical Name: 2-(4-Nitro-2-ethoxyphenyl)pthaliMide
• CAS No.: 106981-60-6
• Molecular Formula: C16H12N2O5
• Molecular Weight: 312.282
• Mol file: 106981-60-6.mol

Synonyms:2-(4-Nitro-2-ethoxyphenyl)pthaliMide;2-(2-Ethoxy-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione;3-Ethyloxy-4-(phthaliMidyl)-1-nitrobenzene

Chemical Property of 2-(4-Nitro-2-ethoxyphenyl)pthaliMide

Chemical Property:

• Boiling Point: 536.5±60.0 °C(Predicted)
• PKA: -3.76±0.20(Predicted)
• PSA: 92.43000
• Density: 1.425±0.06 g/cm3(Predicted)
• LogP: 3.38230
• Solubility.: Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Nitro-2-ethoxyphenyl)pthalimide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Nitro-2-ethoxyphenyl)pthalimide (cas# 106981-60-6) is a compound useful in organic synthesis.

Technology Process of 2-(4-Nitro-2-ethoxyphenyl)pthaliMide

There total 2 articles about 2-(4-Nitro-2-ethoxyphenyl)pthaliMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl bromide (74-96-4) + 2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione (117346-07-3) → 2-(2-ethoxy-4-nitrophenyl)-1H-isoindol-1,3(2H)-dione (106981-60-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 0.833333h; pH=9;

Reference yield:

phthalic anhydride (85-44-9) + aqueous sodium chloride + 5-nitro-2-amino-phenetole (16383-89-4) → 2-(2-ethoxy-4-nitrophenyl)-1H-isoindol-1,3(2H)-dione (106981-60-6)

Guidance literature:

In dichloromethane; water; acetic acid;

Reference yield:

2-(2-ethoxy-4-nitrophenyl)-1H-isoindol-1,3(2H)-dione (106981-60-6) → 3-ethoxy-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)aniline (106981-52-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 50 ℃; for 10h; under 3620.13 Torr; Product distribution / selectivity;

upstream raw materials:

phthalic anhydride

5-nitro-2-amino-phenetole

ethyl bromide

2-(2-hydroxy-4-nitrophenyl)isoindoline-1,3-dione

Downstream raw materials:

3-ethoxy-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)aniline

Refernces

• 1、 -. "Insecticidal heteroaryl substituted phenyl benzoylureas". . . Retrieved 2008/06/13.