4-Chloro-3-ethoxyaniline

Base Information

• Chemical Name: 4-Chloro-3-ethoxyaniline
• CAS No.: 852854-42-3
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922299090
• Mol file: 852854-42-3.mol

Synonyms:4-Chloro-3-ethoxyaniline

Chemical Property of 4-Chloro-3-ethoxyaniline

Chemical Property:

• PSA: 35.25000
• LogP: 2.90210
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

4-Chloro-3-ethoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-3-ethoxyaniline

There total 2 articles about 4-Chloro-3-ethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-chloro-2-ethoxy-4-nitrobenzene (102236-22-6) → 4-chloro-3-ethoxyphenylamine (852854-42-3)

Guidance literature:

With iron; acetic acid; In water; at 110 ℃; for 2.5h;

Reference yield: 50.0%

5-amino-2-chlorophenol (6358-06-1) + ethyl iodide (75-03-6) → 4-chloro-3-ethoxyphenylamine (852854-42-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2.5h;

DOI:10.1248/cpb.c14-00333

Reference yield: 99.0%

2,4-dichloroquinazoline (607-68-1) + 4-chloro-3-ethoxyphenylamine (852854-42-3) → 2-chloro-N4-(4-chloro-3-ethoxyphenyl)quinazoline-4-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; for 18h; Reflux;

upstream raw materials:

1-chloro-2-ethoxy-4-nitrobenzene

5-amino-2-chlorophenol

ethyl iodide

Refernces

• 1、 Numadate, Akiyoshi,Mita, Yusuke,Matsumoto, Yotaro,Fujii, Shinya,Hashimoto, Yuichi. "Development of 2-thioxoquinazoline-4-one derivatives as dual and selective inhibitors of dynamin-related protein 1 (Drp1) and puromycin-sensitive aminopeptidase (PSA)". . p. 979 - 988. Retrieved 2015/02/19.