102236-22-6

Basic information

• Product Name: 1-Chloro-2-ethoxy-4-nitrobenzene
• Synonyms: 1-Chloro-2-ethoxy-4-nitrobenzene
• CAS NO: 102236-22-6
• Molecular Formula: C₈H₈ClNO₃
• Molecular Weight: 201.60702
• Mol File: 102236-22-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-2-ethoxy-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-ethoxy-4-nitrobenzene(102236-22-6)
• EPA Substance Registry System: 1-Chloro-2-ethoxy-4-nitrobenzene(102236-22-6)

Safety Data

• Hazardous Substances Data: 102236-22-6(Hazardous Substances Data)

Usage

General Description

1-chloro-2-ethoxy-4-nitrobenzene is a chemical compound with the molecular formula C8H8ClNO3. It is a pale yellow solid that is mainly used in the manufacture of various pharmaceuticals, dyes, and other organic compounds. This chemical is listed as a hazardous substance and poses a risk to human health and the environment. Exposure to 1-chloro-2-ethoxy-4-nitrobenzene can cause irritation of the skin, eyes, and respiratory system, as well as potential damage to the liver and kidneys. It is important to handle this chemical with caution and follow proper safety measures when working with it.

Upstream product

• 619-10-3 5-nitro-2-chlorophenol 
• 75-03-6 ethyl iodide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 78-10-4 tetraethoxy orthosilicate 
• 861086-20-6 acetic acid-(4-ethoxy-5-chloro-2-nitro-anilide) 
• 116496-76-5 4-acetamido-3-ethoxynitrobenzene 
• 581-08-8 2'-ethoxyacetanilide 
• 171111-66-3 4-ethoxy-5-chloro-2-nitro-aniline 
• 16383-89-4 5-nitro-2-amino-phenetole 
• 97-02-9 2,4-Dinitroanilin 
• 94-70-2 ortho-phenitidine 
• 108761-49-5 acetic acid-(4-ethoxy-3-chloro-anilide) 
• 89981-33-9 3-Chlor-2-aethoxy-5-nitro-anilin 

Downstream Products

• 619-10-3 5-nitro-2-chlorophenol 
• 852854-42-3 4-chloro-3-ethoxyphenylamine 
• 64046-47-5 2-chloro-5-nitrophenyl acetate 
• 85258-92-0 5-(4-Chloro-3-ethoxy-phenyl)-thiazolidine-2,4-dione 
• 85259-09-2 (E)-3-(4-Chloro-3-ethoxy-phenyl)-acrylic acid 
• 85259-46-7 4-chloro-3-ethoxy-benzaldehyde 

Relevant articles and documents

Synthesis of aryl ethers from aromatic carboxylic acids

A silver/copper bimetallic catalyst system promotes the decarboxylative Chan-Evans-Lam alkoxylation of ortho-substituted aromatic carboxylate salts with tetraalkyl orthosilicates or triaryl borates. Non-ortho-substituted carboxylates are alkoxylated via an ortho-C-H-alkoxylation with concomitant cleavage of the carboxylate directing group via protodecarboxylation. This way, meta-substituted carboxylates are converted into para-substituted alkoxyarenes and vice versa. The combined processes provide a convenient synthetic entry to the important class of aromatic ethers from widely available carboxylic acids.

BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I); which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).