methyl 3-(2-Pyridyl)propiolate

Base Information

• Chemical Name: methyl 3-(2-Pyridyl)propiolate
• CAS No.: 72764-93-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933399990
• Mol file: 72764-93-3.mol

Synonyms:methyl 3-(2-Pyridyl)propiolate;Methyl 3-(pyridin-2-yl)propiolate

Chemical Property of methyl 3-(2-Pyridyl)propiolate

Chemical Property:

• Boiling Point: 274.4±13.0 °C(Predicted)
• PKA: 1.46±0.19(Predicted)
• PSA: 39.19000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 0.60610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-(2-Pyridyl)propiolate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(2-Pyridyl)propiolate

There total 3 articles about methyl 3-(2-Pyridyl)propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethynylpyridine (1945-84-2) + methyl chloroformate (79-22-1) → methyl 3-(pyridin-2-yl)propiolate (72764-93-3)

Guidance literature:

2-ethynylpyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c02567

Reference yield:

2-ethynylpyridine (1945-84-2) + carbon dioxide (124-38-9,18923-20-1) + methyl iodide (74-88-4) → methyl 3-(pyridin-2-yl)propiolate (72764-93-3)

Guidance literature:

2-ethynylpyridine; carbon dioxide; With cesium fluoride; trimethylsilylacetylene; In dimethyl sulfoxide; at 30 ℃; for 20h;

methyl iodide; In dimethyl sulfoxide; at 30 ℃; for 5h;

DOI:10.1039/c7nj01779k

Reference yield:

→ methyl 3-(pyridin-2-yl)propiolate (72764-93-3)

Guidance literature:

Pyrazolon 5, HNO3, Me. (zusaetz. m. MeOH-Addukt Prod.6);

upstream raw materials:

2-ethynylpyridine

carbon dioxide

methyl iodide

methyl chloroformate

Downstream raw materials:

methyl 3-(pyridin-2-yl)propanoate

Methyl Z-3-(2-Pyridinyl)-2-propenoate

(E)-3-(pyridin-2-yl)acrylamide

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