5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole

Base Information

• Chemical Name: 5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole
• CAS No.: 1012879-56-9
• Molecular Formula: C10H10FN3
• Molecular Weight: 191.208
• Hs Code.: 2933199090
• Mol file: 1012879-56-9.mol

Synonyms:5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole;3-(2-fluorophenyl)-1-methyl-1H-Pyrazol-5-amine

Chemical Property of 5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole

Chemical Property:

• PSA: 43.84000
• LogP: 2.38960

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-3-(2-fluorophenyl)-1-methylpyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-3-(2-fluorophenyl)-1-methylpyrazole is a versatile reactant used in the preparation of thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors useful in the pain treatment.

Technology Process of 5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole

There total 2 articles about 5-AMino-3-(2-fluorophenyl)-1-Methylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3-(2-fluorophenyl)-3-oxo-propanenitrile (31915-26-1) + methylhydrazine (60-34-4) → 5-amino-3-(2-fluorophenyl)-1-methylpyrazole (1012879-56-9)

Guidance literature:

In methanol; at 120 ℃; for 7h;

Reference yield:

→ 5-amino-3-(2-fluorophenyl)-1-methylpyrazole (1012879-56-9)

Guidance literature:

Reference yield: 67.0%

5-amino-3-(2-fluorophenyl)-1-methylpyrazole (1012879-56-9) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → 3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridin-6(7H)-one (1312949-07-7)

Guidance literature:

With acetic acid; at 150 ℃; for 1.5h; microwave irradiation;

upstream raw materials:

3-(2-fluorophenyl)-3-oxo-propanenitrile

methylhydrazine

Downstream raw materials:

3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo-[3,4-b]pyridin-6(7H)-one

ethyl 2-(3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetate

2-(3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetic acid

(S)-2-(3-(2-fluorophenyl)-1-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

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