3-Chloro-4-ethoxybenzonitrile

Base Information

• Chemical Name: 3-Chloro-4-ethoxybenzonitrile
• CAS No.: 916596-02-6
• Molecular Formula: C9H8ClNO
• Molecular Weight: 181.61892
• Hs Code.: 2926909090
• Mol file: 916596-02-6.mol

Synonyms:3-Chloro-4-ethoxybenzonitrile

Chemical Property of 3-Chloro-4-ethoxybenzonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 2.61038

Purity/Quality:

99%min ^*data from raw suppliers

3-Chloro-4-ethoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-4-ethoxybenzonitrile

There total 3 articles about 3-Chloro-4-ethoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C10H12ClNO2 (1428637-01-7) → 3-chloro-4-ethoxybenzonitrile (916596-02-6)

Guidance literature:

With [Ru(η⁶-p-cymene)Cl₂]₂; diphenyl acetylene; In isopropyl alcohol; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c3cc41124a

Reference yield:

2-chloro-4-cyanophenol (2315-81-3) + ethyl iodide (75-03-6) → 3-chloro-4-ethoxybenzonitrile (916596-02-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 16h;

Reference yield:

4-ethoxybenzonitrile (25117-74-2) → 3-chloro-4-ethoxybenzonitrile (916596-02-6)

Guidance literature:

With sodium persulfate; tris(bipyridine)ruthenium(II) dichloride hexahydrate; sodium chloride; In water; acetonitrile; at 25 ℃; for 15h; Irradiation;

DOI:10.1039/c7sc03010j

upstream raw materials:

C₁₀H₁₂ClNO₂

4-ethoxybenzonitrile

2-chloro-4-cyanophenol

ethyl iodide

Refernces

• 1、 Zhang, Lei,Hu, Xile. "Room temperature C(sp2)-H oxidative chlorination: Via photoredox catalysis". . p. 7009 - 7013. Retrieved 2017/10/05.