1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone

Base Information

• Chemical Name: 1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone
• CAS No.: 352328-55-3
• Molecular Formula: C7H9N3OS
• Molecular Weight: 183.234
• Mol file: 352328-55-3.mol

Synonyms:1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone;1-[4-amino-2-(methylsulfanyl)pyrimidin-5-yl]ethan-1-one;1-(4-Amino-2-(methylthio)pyrimidin-5-yl)ethanone

Chemical Property of 1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone

Chemical Property:

• PSA: 94.90000
• LogP: 0.91340
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone

There total 5 articles about 1-(4-AMino-2-Methylsulfanyl-pyriMidin-5-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanol (352328-54-2) → 1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanone (352328-55-3)

Guidance literature:

With manganese(IV) oxide; In toluene; at 120 ℃; for 4h;

Reference yield:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) → 1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanone (352328-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / tetrahydrofuran; diethyl ether

2: 42 percent / 4A molecular sieves; N-methyl morpholine oxide; tetrapropylammonium perruthenate / CH₂Cl₂ / 20 °C

With 4-methyltetrahydro-1,4-oxazin-3-one; tetrapropylammonium perruthennate; 4 A molecular sieve; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jm049355+

Reference yield:

(4-amino-2-(methylthio)pyrimidin-5-yl)methanol (588-36-3) → 1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanone (352328-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / MnO₂ / CHCl₃

2: 88 percent / tetrahydrofuran; diethyl ether

3: 42 percent / 4A molecular sieves; N-methyl morpholine oxide; tetrapropylammonium perruthenate / CH₂Cl₂ / 20 °C

With 4-methyltetrahydro-1,4-oxazin-3-one; manganese(IV) oxide; tetrapropylammonium perruthennate; 4 A molecular sieve; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;

DOI:10.1021/jm049355+

upstream raw materials:

1-(4-amino-2-methylsulfanylpyrimidin-5-yl)ethanol

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

(4-amino-2-(methylthio)pyrimidin-5-yl)methanol

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

5-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

Refernces

• 1、 VanderWel, Scott N.,Harvey, Patricia J.,McNamara, Dennis J.,Repine, Joseph T.,Keller, Paul R.,Quin III, John,Booth, R. John,Elliott, William L.,Dobrusin, Ellen M.,Fry, David W.,Toogood, Peter L.. "Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4". . p. 2371 - 2387. Retrieved 2007/10/03.