1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea

Base Information

• Chemical Name: 1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea
• CAS No.: 16018-61-4
• Molecular Formula: C13H13 Cl N4 O
• Molecular Weight: 276.725
• Hs Code.: 2933599090
• Mol file: 16018-61-4.mol

Synonyms:Urea,1-(p-chlorophenyl)-3-(4,6-dimethyl-2-pyrimidinyl)- (6CI,8CI)

Chemical Property of 1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 70.40000
• Density: 1.378g/cm³
• LogP: 3.47740

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(4-CHLOROPHENYL)-N'-(4,6-DIMETHYL-2-PYRIMIDINYL)UREA AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea

There total 6 articles about 1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.5%

2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8) + carbon monoxide (201230-82-2) + 4-chlorobenzonitrile (100-00-5) → 1-(4-chloro-phenyl)-3-(4,6-dimethyl-pyrimidin-2-yl)-urea (16018-61-4)

Guidance literature:

With selenium; triethylamine; In toluene; at 150 ℃; for 4h;

Reference yield:

2-chloro-4,6-dimethylpyrimidine (4472-44-0) → 1-(4-chloro-phenyl)-3-(4,6-dimethyl-pyrimidin-2-yl)-urea (16018-61-4)

Guidance literature:

Multi-step reaction with 3 steps

2: H₂SO₄

With sulfuric acid;

DOI:10.1039/jr9530001725

Reference yield:

(4,6-dimethylpyrimidin-2-yl)cyanamide (55474-90-3) → 1-(4-chloro-phenyl)-3-(4,6-dimethyl-pyrimidin-2-yl)-urea (16018-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄

With sulfuric acid;

DOI:10.1039/jr9530001725

upstream raw materials:

2-ureido-4,6-dimethylpyrimidine

p-chloroaniline hydrochloride

2-Amino-4,6-dimethylpyrimidine

carbon monoxide

Refernces