N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide

Base Information Edit

Chemical Name:N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide
CAS No.:1083326-21-9
Molecular Formula:C11H6BrClF2N2O2S
Molecular Weight:383.601
Hs Code.:
Mol file:1083326-21-9.mol

Synonyms:N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide

Suppliers and Price of N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide Edit

Chemical Property:

Boiling Point:439.6±55.0 °C(Predicted)
PKA:4.86±0.40(Predicted)
PSA：67.44000
Density:1.841±0.06 g/cm3(Predicted)
LogP:4.73030

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide

There total 4 articles about N-(5-broMo-2-chloropyridin-3-yl)-2,4-difluorobenzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 13918-92-8
2,4-difluorobenzene-1-sulfonyl chloride

: 1083326-21-9
N-(5-bromo-2-chloropyridin-3-yl )-2,4-difluorobenzenesulfonamide

Guidance literature:: 3-amino-5-bromo-2-chloropyridine; 2,4-difluorobenzene-1-sulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 12h; Cooling with ice;

With potassium carbonate; In methanol; water; at 80 ℃;
DOI:10.1016/j.bioorg.2021.105405

Reference yield: 71.3%

: 1083326-21-9
N-(5-bromo-2-chloropyridin-3-yl )-2,4-difluorobenzenesulfonamide

Guidance literature:: With pyridine; at 23 ℃; for 24h;

With sodium hydroxide; In methanol; at 23 ℃; for 1h;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1083326-21-9
N-(5-bromo-2-chloropyridin-3-yl )-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; tin(ll) chloride / 1 h / Reflux

2: pyridine / dichloromethane / 0 - 20 °C

With pyridine; ethanol; tin(ll) chloride; In dichloromethane;