Encainide hydrochloride

Base Information

• Chemical Name: Encainide hydrochloride
• CAS No.: 66794-74-9
• Molecular Formula: C22H29ClN2O2
• Molecular Weight: 352.4699
• European Community (EC) Number: 636-281-7
• NSC Number: 299238
• UNII: 4CH7J36N9S
• DSSTox Substance ID: DTXSID2049004
• Wikidata: Q27126935
• NCI Thesaurus Code: C75131
• Metabolomics Workbench ID: 60836
• ChEMBL ID: CHEMBL2106155
• Mol file: 66794-74-9.mol

Synonyms:Encainide;Encainide Hydrochloride;Encainide Hydrochloride, (+-)-Isomer;Encainide, (+)-Isomer;Encainide, (-)-Isomer;Enkaid;MJ 9067;MJ-9067;MJ9067

Chemical Property of Encainide hydrochloride

Chemical Property:

• Melting Point: 131.5-132.5 °C
• Boiling Point: 439.9°Cat760mmHg
• Flash Point: 219.8°C
• PSA: 41.57000
• Density: 1.106g/cm³
• LogP: 5.17730
• Storage Temp.: 2-8°C
• Solubility.: H2O: >25mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 388.1917559
• Heavy Atom Count: 27
• Complexity: 434

Purity/Quality:

98%,99%, ^*data from raw suppliers

Encainide hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC.Cl
• Description: Encainide is an oral and injectable antiarrhythmic structurally related to flecainide. It is reportedly useful in the treatment of symptomatic and life-threatening ventricular arrhythmias. While it appears to have higher efficacy than quinine, the morbidity and mortality rates are comparable.
• Therapeutic Function: Antiarrhythmic

Technology Process of Encainide hydrochloride

There total 5 articles about Encainide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + 2-(ortho-aminophenethyl)-1-methylpiperidine (37611-80-6) → 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide hydrochloride (66794-74-9)

Guidance literature:

In acetone; for 16h; Yield given;

DOI:10.1002/jhet.5570300321

Reference yield:

1,2-dimethylpyridinium methosulfate (2037-39-0) → 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide hydrochloride (66794-74-9)

Guidance literature:

Multi-step reaction with 4 steps

1: piperidine / CH₂Cl₂ / 2 h

2: 96 percent / glac. AcOH, Ac₂O, KOAc / 2 h / Heating

3: hydrogen / Pt/C / aq. ethanol / 16 h / 103.4 Torr

4: acetone / 16 h

With piperidine; hydrogen; potassium acetate; acetic anhydride; acetic acid; platinum on activated charcoal; In ethanol; dichloromethane; acetone;

DOI:10.1002/jhet.5570300321

Reference yield:

2-(1-methylpyridinium-2-yl)-1-(2-nitrophenyl)ethanol methyl sulfate → 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide hydrochloride (66794-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / glac. AcOH, Ac₂O, KOAc / 2 h / Heating

2: hydrogen / Pt/C / aq. ethanol / 16 h / 103.4 Torr

3: acetone / 16 h

With hydrogen; potassium acetate; acetic anhydride; acetic acid; platinum on activated charcoal; In ethanol; acetone;

DOI:10.1002/jhet.5570300321

upstream raw materials:

4-methoxy-benzoyl chloride

2-(ortho-aminophenethyl)-1-methylpiperidine

1,2-dimethylpyridinium methosulfate

2-nitro-benzaldehyde

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