1-Adamantanamine,hydrochloride.(L-)- (8CI)

Base Information

• Chemical Name: 1-Adamantanamine,hydrochloride.(L-)- (8CI)
• CAS No.: 13878-11-0
• Molecular Weight: 187.70962
• Mol file: 13878-11-0.mol

Synonyms:1-Adamantanamine,hydrochloride.(L-)- (8CI);Tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride, (S)-

Chemical Property of 1-Adamantanamine,hydrochloride.(L-)- (8CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Adamantanamine,hydrochloride.(L-)- (8CI)

There total 21 articles about 1-Adamantanamine,hydrochloride.(L-)- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Adamantanamine (768-94-5) → amantadine hydrochloride (665-66-7,13878-11-0)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 2h; Reflux;

DOI:10.1080/00397911.2015.1096943

Reference yield: 99.0%

1-Azidoadamantane (24886-73-5) → amantadine hydrochloride (665-66-7,13878-11-0)

Guidance literature:

With propan-1-ol; 2,2'-azobis(isobutyronitrile); phenylsilane; bis(tri-n-butyltin)oxide; In benzene; Heating;

DOI:10.1021/jo9721958

Reference yield: 99.0%

2,2,2-trichloroethyl ((3s,5s,7s)-adamantan-1-yl)carbamate (17341-91-2) → amantadine hydrochloride (665-66-7,13878-11-0)

Guidance literature:

2,2,2-trichloroethyl ((3s,5s,7s)-adamantan-1-yl)carbamate; With acetic acid; zinc;

With acetyl chloride; In methanol; Heating;

DOI:10.1002/chem.200702027

upstream raw materials:

1-(Chloroamino)adamantane

1-Azidoadamantane

adamantylmagnesium bromide

1-Adamantanamine

Downstream raw materials:

1-(2-hydroxyethylamino)adamantane

N-Adamantan-1-yl-N'-<2-fluor-aethyl>-harnstoff

3-(adamantan-1-ylamino)propan-1-ol

1-(5-bromonicotinoylamino)adamantane