4-Acetyl-N,N-dimethylbenzamide

Base Information

• Chemical Name: 4-Acetyl-N,N-dimethylbenzamide
• CAS No.: 1008119-09-2
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 2924299090
• Mol file: 1008119-09-2.mol

Synonyms:4-Acetyl-N,N-dimethylbenzamide

Chemical Property of 4-Acetyl-N,N-dimethylbenzamide

Chemical Property:

• Boiling Point: 357.4±25.0 °C(Predicted)
• PKA: -1.76±0.70(Predicted)
• PSA: 37.38000
• Density: 1.084±0.06 g/cm3(Predicted)
• LogP: 1.59100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Acetyl-N,N-dimethylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Acetyl-N,N-dimethylbenzamide

There total 13 articles about 4-Acetyl-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-Iodoacetophenone (13329-40-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-acetyl-N,N-dimethylbenzamide (1008119-09-2)

Guidance literature:

With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; at 135 ℃; for 6h; Inert atmosphere;

DOI:10.1021/jo200754v

Reference yield: 87.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 4-acetyl-benzoic acid (586-89-0) → 4-acetyl-N,N-dimethylbenzamide (1008119-09-2)

Guidance literature:

With 1,1'-carbonyldiimidazole; at 160 - 165 ℃; for 1h;

DOI:10.3184/174751913X13602686612047

Reference yield: 85.0%

N,N-dimethylformamide diisopropyl acetal (18503-89-4) + para-bromoacetophenone (99-90-1) → 4-acetyl-N,N-dimethylbenzamide (1008119-09-2)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

DOI:10.1002/hlca.202100162

upstream raw materials:

4-acetylbenzoyl chloride

dimethyl amine

4-acetyl-benzoic acid

N,n-dimethyl-p-ethyl-benzamide

Downstream raw materials:

1-[4-(dimethylaminomethyl)phenyl]ethanone

(E)-4-acetyl-N,N-dimethyl-2-(prop-1-en-1-yl)benzamide

4-(5-(1,1-dimethyl-2-oxo-2-(1,3,4-thiadiazol-2-ylamino)ethyl)-8-vinyl-5H-pyrido[3',2':5,6]pyrano[2,3-b]pyridin-2-yl)-N,N-dimethylbenzamide

C₂₇H₂₉N₃O₄S

Refernces

• 1、 Sawant, Dinesh N.,Wagh, Yogesh S.,Bhatte, Kushal D.,Bhanage, Bhalchandra M.. "Palladium-catalyzed carbon-monoxide-free aminocarbonylation of aryl halides using N-substituted formamides as an amide source". . p. 5489 - 5494. Retrieved 2011.
• 2、 -. "NOVEL GPR119 AGONIST COMPOUNDS". . . Retrieved 2017/10/26.