Magnesium Sulfate

Base Information

• Chemical Name: Magnesium Sulfate
• CAS No.: 7487-88-9
• Deprecated CAS: 139939-75-6,849607-35-8,849607-35-8
• Molecular Formula: MgSO4
• Molecular Weight: 120.369
• Hs Code.: 2833210000
• European Community (EC) Number: 231-298-2,242-691-3,686-508-9
• ICSC Number: 1197
• UNII: ML30MJ2U7I
• DSSTox Substance ID: DTXSID6042105
• Nikkaji Number: J3.103H
• Wikipedia: Magnesium sulfate,Magnesium_sulfate
• Wikidata: Q288266
• NCI Thesaurus Code: C623,C66051
• RXCUI: 6585,1311625
• ChEMBL ID: CHEMBL2021423
• Mol file: 7487-88-9.mol

Synonyms:Heptahydrate Magnesium Sulfate;Magnesium Sulfate;Magnesium Sulfate, Heptahydrate;Sulfate, Magnesium

Chemical Property of Magnesium Sulfate

Chemical Property:

• Appearance/Colour: White crystalline powder
• Melting Point: 1124 °C
• Boiling Point: 330 °C at 760 mmHg
• PSA: 88.64000
• Density: 2.66 g/cm³
• LogP: -0.25720
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 119.9367713
• Heavy Atom Count: 6
• Complexity: 62.2

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Metals, Inorganic Compounds
• Canonical SMILES: [O-]S(=O)(=O)[O-].[Mg+2]
• Recent ClinicalTrials: Intravenous Administration of Magnesium Sulfate in Laparoscopic Hysterectomy Cases
• Recent EU Clinical Trials: POMPAE trial: Peri-Operative Magnesium infusion to Prevent Atrial fibrillation Evaluated.
• Inhalation Risk: A harmful concentration of airborne particles can be reached quickly , especially if powdered.
• Effects of Short Term Exposure: The substance is mildly irritating to the eyes and respiratory tract.
• Chemical Properties and Role: Magnesium sulfate is a magnesium salt with sulfate as the counterion. It serves various roles such as an anticonvulsant, cardiovascular drug, calcium channel blocker, anesthetic, tocolytic agent, anti-arrhythmia drug, analgesic, and fertilizer. Magnesium plays a crucial role in the physiological function of the human body.
• Application in Regional Anesthesia: Numerous studies have demonstrated the safety and effectiveness of adding magnesium sulfate to various regional anesthesia techniques. Meta-analyses have shown that combining magnesium sulfate with local anesthetics in nerve blocks can lead to prolonged postoperative analgesia. The addition of magnesium sulfate to bupivacaine during transversus abdominis plane (TAP) block and subclavian brachial plexus nerve block resulted in a longer duration of analgesia and reduced postoperative morphine requirements.
• Enhancement of Local Anesthetics in Nerve Blocks: With the widespread use of ultrasound, nerve blocks have become more prevalent but are limited by shorter duration and suboptimal analgesia. Magnesium sulfate, as a local anesthetic adjuvant for peripheral nerve blocks, enhances the effects of local anesthetics.
• Neuroprotection in Preterm Birth: Magnesium sulfate (MgSO4) has been proposed as a crucial intervention for preventing neurologic disability associated with preterm birth. It is readily accessible, cost-effective, and has been recommended as a mandatory component of managing inevitable preterm birth. MgSO4 administration has been shown to reduce the risk of severe neurologic deficits, particularly cerebral palsy, in appropriately selected patients. Guidelines recommend a standard regimen of 4g intravenous loading dose followed by 1g/h maintenance dose for up to 24 hours, but recent studies suggest higher doses may provide maximum protective effect.

Technology Process of Magnesium Sulfate

There total 117 articles about Magnesium Sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.7%

copper(ll) sulfate pentahydrate + magnesium oxide → magnesium sulfate (7487-88-9) + copper(II) oxide

Guidance literature:

In solid; byproducts: H2O; mixt. heating in derivatograph in Pt crucible at 10 K/min in air up to 850°C; TG, DTG, DTA;

DOI:10.1016/s0040-6031(97)00199-8

Reference yield: 57.64%

→ 2-phenylpropane-1, 3-diol (1570-95-2) + magnesium sulfate (7487-88-9)

Guidance literature:

Reference yield:

aluminum(III) sulfate + magnesium chloride (7786-30-3) → hydrogenchloride (7647-01-0,15364-23-5) + aluminum oxide (1333-84-2,1344-28-1) + magnesium sulfate (7487-88-9)

Guidance literature:

upstream raw materials:

sulfur dioxide

oxygen

sulfuric acid

sodium hydrogen sulfate

Downstream raw materials:

2,3-dihydro-2,2,5-trimethylbenzofuran

2,3-dihydro-2,2,7-trimethylbenzofuran

N-Phenylhydroxylamine

Nitrosobenzene

Refernces

• 1、 Crnkovic,Milioli,Pagliuso. "Kinetics study of the SO2 sorption by Brazilian dolomite using thermogravimetry". . p. 161 - 166. Retrieved 2006.
• 2、 Vosburgh, W. C.,Dibeler, V. H.,Parks, H. C.,Miller, W. J.. "". . p. 1472 - 1473. Retrieved 1940.
• 3、 Song, Ying,Feng, Mei-Ling,Wu, Zhao-Feng,Huang, Xiao-Ying. "Solvent-assisted construction of diverse Mg-TDC coordination polymers". . p. 1348 - 1357. Retrieved 2015.
• 4、 Ford, A. N.,Helou, G.,Tariq, S. A.. "". . p. 395 - 400. Retrieved 1990.
• 5、 Lakshmanan,Prasad,Ponraju,Krishnan. "A novel method of non-violent dissolution of sodium metal in a concentrated aqueous solution of Epsom salt". . p. 3460 - 3468. Retrieved 2004.
• 6、 Prasad, T. P.. "". . p. 1505 - 1510. Retrieved 1987.
• 7、 Jablonski,Przepiera. "Kinetic model for the reaction of ilmenite with sulphuric acid". . p. 583 - 590. Retrieved 2001.
• 8、 Gerle, Anna,Piotrowski, Jerzy,Podwórny, Jacek. "Kinetics of the topochemical reaction of the solid solutions of magnesia spinels: Mg(Cr0.5Fe0.5)2O4, Mg(Al0.5Cr0.5)2O4, Mg(Al0.5Fe0.5)2O4 with sulphur oxides". . . Retrieved 2019/08/01.