5-Methyl-indole-6-carboxylic acid Methyl ester

Base Information

• Chemical Name: 5-Methyl-indole-6-carboxylic acid Methyl ester
• CAS No.: 1227270-85-0
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.21054
• Mol file: 1227270-85-0.mol

Synonyms:5-Methyl-indole-6-carboxylic acid Methyl ester;methyl 5-methyl-1H-indole-6-carboxylate

Chemical Property of 5-Methyl-indole-6-carboxylic acid Methyl ester

Chemical Property:

• Boiling Point: 334.9±22.0 °C(Predicted)
• PKA: 15.97±0.30(Predicted)
• Density: 1.212±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl5-Methyl-1H-indole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5-Methyl-indole-6-carboxylic acid Methyl ester

There total 1 articles about 5-Methyl-indole-6-carboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.88%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 6-bromo-5-methyl-1H-indole (248602-16-6) → methyl 5-methyl-1H-indole-6-carboxylate (1227270-85-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 70 - 100 ℃; for 16h; under 2585.81 - 22502.3 Torr;

Reference yield: 2.78%

3-phenyl-1H-indazol-5-amine (395099-05-5) + methyl 5-methyl-1H-indole-6-carboxylate (1227270-85-0) + trifluoroacetic acid (76-05-1) → 5-methyl-N-(3-phenyl-1H-indazol-5-yl)-1H-indole-6-carboxamide trifluoroacetate

Guidance literature:

3-phenyl-1H-indazol-5-amine; methyl 5-methyl-1H-indole-6-carboxylate; With trimethylaluminum; In toluene; at 25 - 60 ℃; for 24h;

trifluoroacetic acid;

upstream raw materials:

methanol

carbon monoxide

6-bromo-5-methyl-1H-indole

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