(5-Bromo-benzo[b]thiophen-2-yl)-methanol

Base Information

• Chemical Name: (5-Bromo-benzo[b]thiophen-2-yl)-methanol
• CAS No.: 13771-72-7
• Molecular Formula: C₉H₇BrOS
• Molecular Weight: 243.124
• Hs Code.: 2934999090
• Mol file: 13771-72-7.mol

Synonyms:(5-Bromo-benzo[b]thiophen-2-yl)-methanol;5-bromo-benzo[b]thiophene-2-methanol

Chemical Property of (5-Bromo-benzo[b]thiophen-2-yl)-methanol

Chemical Property:

• Boiling Point: 379.9±27.0 °C(Predicted)
• PKA: 13.69±0.10(Predicted)
• PSA: 48.47000
• Density: 1.699±0.06 g/cm3(Predicted)
• LogP: 3.15610

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromobenzo[b]thiophene-2-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromobenzo[b]thiophene-2-methanol is a pharmacologically active benzo[b]thiophene derivatives.

Technology Process of (5-Bromo-benzo[b]thiophen-2-yl)-methanol

There total 4 articles about (5-Bromo-benzo[b]thiophen-2-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester (13771-68-1) → (5-bromobenzo[b]thiophen-2-yl)methanol (13771-72-7)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 60 ℃; for 3h;

Reference yield:

5-bromo-1-benzothiophene-2-carboxylic acid (7312-10-9) → (5-bromobenzo[b]thiophen-2-yl)methanol (13771-72-7)

Guidance literature:

5-bromo-1-benzothiophene-2-carboxylic acid; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With water; In tetrahydrofuran;

Reference yield:

5-bromo-2-fluorobenzaldehyde (93777-26-5) → (5-bromobenzo[b]thiophen-2-yl)methanol (13771-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dimethyl sulfoxide / 2 h / 95 °C

2: lithium borohydride / tetrahydrofuran / 3 h / 60 °C

With lithium borohydride; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

5-bromobenzo[b]thiophene-2-carboxylic acid ethyl ester

5-bromo-1-benzothiophene-2-carboxylic acid

5-bromo-2-fluorobenzaldehyde

Downstream raw materials:

5-Bromo-2-chloromethyl-benzo[b]thiophene

5-bromobenzo[b]thiophene-2-carboxaldehyde

5-bromobenzo[b]thiophene-2-carbonitrile