3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE

Base Information

• Chemical Name: 3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE
• CAS No.: 1001054-49-4
• Molecular Formula: C20H30N2
• Molecular Weight: 298.472
• Mol file: 1001054-49-4.mol

Synonyms:3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE;3,9-Diazaspiro[5.5]undecane, 3-cyclobutyl-9-(phenylmethyl)-

Chemical Property of 3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE

Chemical Property:

• PSA: 6.48000
• LogP: 3.79290

Purity/Quality:

98%min ^*data from raw suppliers

3,9-DIAZASPIRO[5.5]UNDECANE-3-CYCLOBUTYL-9-(PHENYLMETHYL) 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE

There total 4 articles about 3-BENZYL-9-CYCLOBUTYL-3,9-DIAZASPIRO[5.5]UNDECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzyl-3,9-diazaspiro[5.5]undecane (189333-49-1) + cyclobutanone (1191-95-3) → 3-benzyl-9-cyclobutyl-3,9-diazaspiro[5.5]undecane (1001054-49-4)

Guidance literature:

3-benzyl-3,9-diazaspiro[5.5]undecane; cyclobutanone; With acetic acid; In dichloromethane; at 0 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 3-benzyl-9-cyclobutyl-3,9-diazaspiro[5.5]undecane (1001054-49-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonia / methanol / 48 h / 0 °C

2.1: sulfuric acid / 2 h / Heating / reflux

2.2: 0 °C / pH 8

3.1: lithium aluminium tetrahydride / diethyl ether / 8 h / Heating / reflux

4.1: acetic acid / dichloromethane / 0.5 h / 0 °C

4.2: 20 °C

With lithium aluminium tetrahydride; sulfuric acid; ammonia; acetic acid; In methanol; diethyl ether; dichloromethane;

Reference yield:

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione (189333-48-0) → 3-benzyl-9-cyclobutyl-3,9-diazaspiro[5.5]undecane (1001054-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 8 h / Heating / reflux

2.1: acetic acid / dichloromethane / 0.5 h / 0 °C

2.2: 20 °C

With lithium aluminium tetrahydride; acetic acid; In diethyl ether; dichloromethane;

upstream raw materials:

3-benzyl-3,9-diazaspiro[5.5]undecane

cyclobutanone

1-phenylmethyl-4-piperidone

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione