3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE

Base Information

• Chemical Name: 3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE
• CAS No.: 189333-49-1
• Molecular Formula: C16H24N2
• Molecular Weight: 244.38
• Hs Code.: 2933990090
• Mol file: 189333-49-1.mol

Synonyms:NSC 116047;

Chemical Property of 3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE

Chemical Property:

• Vapor Pressure: 2.67E-05mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 357.738 °C at 760 mmHg
• PKA: 11.02±0.20(Predicted)
• Flash Point: 135.985 °C
• PSA: 15.27000
• Density: 1.057 g/cm³
• LogP: 2.91890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Benzyl-3,9-diazaspiro[5.5]undecane 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE

There total 10 articles about 3-BENZYL-3,9-DIAZA-SPIRO[5.5]UNDECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

1'-benzyl-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,4'-piperidine]-2,4,6,8-tetraone (1176981-06-8) → 3-benzyl-3,9-diazaspiro[5.5]undecane (189333-49-1)

Guidance literature:

1'-benzyl-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,4'-piperidine]-2,4,6,8-tetraone; With sodium bis(2-methoxyethoxy)aluminium dihydride; In xylene; at 0 - 127 ℃;

With water; sodium hydroxide; In xylene; at 0 ℃; for 0.583333h;

Reference yield: 77.81%

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione (189333-48-0) → 3-benzyl-3,9-diazaspiro[5.5]undecane (189333-49-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 65 ℃; for 3h;

Reference yield:

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione hydrochloride (1176981-07-9) → 3-benzyl-3,9-diazaspiro[5.5]undecane (189333-49-1)

Guidance literature:

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione hydrochloride; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Reflux;

With water; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione

1'-benzyl-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,4'-piperidine]-2,4,6,8-tetraone

9-benzyl-3,9-diazaspiro[5.5]undecane-2,4-dione hydrochloride

1-phenylmethyl-4-piperidone

Downstream raw materials:

3-benzyl-9-cyclobutyl-3,9-diazaspiro[5.5]undecane

3-benzyl-9-methyl-3,9-diaza-spiro[5.5]undecane

C₃₇H₄₁F₆N₃O

tert-butyl 9-benzyl-3,9-diazaspiro[5.5]undecane-3-carboxylate

Refernces

• 1、 -. "3,9- DIAZASPIRO[5,5] UNDECANE COMPOUND AS FLT3 AND AXL INHIBITORS". Paragraph 0019; 0025; 0028. . Retrieved 2021/08/05.
• 2、 -. "Polymorphism of novel spiroarylphosphine oxide". Paragraph 0125; 0135-0137. . Retrieved 2019/11/20.