Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate
• CAS No.: 754219-01-7
• Molecular Formula: C₇H₉IN₂O₂
• Molecular Weight: 280.065
• Mol file: 754219-01-7.mol

Synonyms:Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate

Chemical Property of Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 1.20140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.00% ^*data from raw suppliers

Ethyl5-iodo-1-methyl-1H-pyrazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate

There total 6 articles about Ethyl 5-iodo-1-methyl-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (31037-02-2) → ethyl 5-iodo-1-methyl-1H-pyrazol-4-carboxylate (754219-01-7)

Guidance literature:

ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate; With hydrogenchloride; sodium nitrite;

With potassium iodide; at 60 ℃; for 12h;

DOI:10.3762/bjoc.5.64

Reference yield: 42.0%

ethyl 3-iodo-1H-pyrazole-4-carboxylate + methyl iodide (74-88-4) → ethyl 5-iodo-1-methyl-1H-pyrazol-4-carboxylate (754219-01-7) + ethyl 3-iodo-1-methyl-1H-pyrazole-4-carboxylate (799835-39-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 15h;

Reference yield: 40.0%

ethyl 5-iodo-1H-pyrazole-4-carboxylate + methyl iodide (74-88-4) → ethyl 5-iodo-1-methyl-1H-pyrazol-4-carboxylate (754219-01-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 28 ℃; for 3h;

upstream raw materials:

ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

methyl iodide

3-amino-4-pyrazolecarboxylic acid ethyl ester

ethyl 5-amino-1H-pyrazole-4-carboxylate

Downstream raw materials:

5-iodo-1-methyl-1H-pyrazole-4-carboxylic acid

Refernces

• 1、 -. "INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF". Paragraph 0472. . Retrieved 2018/07/04.
• 2、 -. "NOVEL COMPOUND HAVING 4-PYRIDYLALKYLTHIO GROUP AS SUBSTITUENT". Page/Page column 58. . Retrieved 2008/06/13.