6-Methylquinoline

Base Information

• Chemical Name: 6-Methylquinoline
• CAS No.: 91-62-3
• Molecular Formula: C10H9N
• Molecular Weight: 143.188
• Hs Code.: 2933.49
• European Community (EC) Number: 202-084-6
• NSC Number: 4152
• UNII: K14453I13N
• DSSTox Substance ID: DTXSID3020887
• Nikkaji Number: J800A
• Wikidata: Q27281809
• Metabolomics Workbench ID: 45890
• ChEMBL ID: CHEMBL1412508
• Mol file: 91-62-3.mol

Synonyms:6-methylquinoline

Chemical Property of 6-Methylquinoline

Chemical Property:

• Appearance/Colour: clear light yellow to light orange liquid
• Melting Point: -22 °C
• Refractive Index: 1.612 - 1.617
• Boiling Point: 258.6 °C at 760 mmHg
• PKA: 5.21±0.10(Predicted)
• Flash Point: 104.4 °C
• PSA: 12.89000
• Density: 1.076 g/cm³
• LogP: 2.54320
• Storage Temp.: Store below +30°C.
• Sensitive.: Light Sensitive
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: Not miscible or difficult to mix with water.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 143.073499291
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

6-Methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-38-68-36/37/38
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N=CC=C2
• Uses: 6-Methylquinoline can be used as primary carbon source in culture of Pseudomonas putida QP1. 6-Methylquinoline was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and fluorescent probes for determination of chloride in biological systems.

Technology Process of 6-Methylquinoline

There total 64 articles about 6-Methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-methyl-1,2,3,4 tetrahydroquinoline (91-61-2) → 6-methylquinoline (91-62-3)

Guidance literature:

With iron(III) chloride; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In chlorobenzene; at 120 ℃; for 11h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c00043

Reference yield: 97.0%

6-methylquinoline-N-oxide (4053-42-3) → 6-methylquinoline (91-62-3)

Guidance literature:

With styrene; tris(bipyridine)ruthenium(II) dichloride hexahydrate; hydrazine hydrate; In dimethyl sulfoxide; at 20 ℃; for 4h; Reagent/catalyst; Solvent; chemoselective reaction; Catalytic behavior; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.8b03446

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + trimethyleneglycol (504-63-2) → 6-methylquinoline (91-62-3)

Guidance literature:

With tetrachloromethane; iron(III) chloride hexahydrate; at 150 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1134/S1070363215120105

upstream raw materials:

6-methyl-1,2,3,4 tetrahydroquinoline

mercury(II) diacetate

p-toluidine

glycerol

Downstream raw materials:

6-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde

2-(4-chloro-phenyl)-6-methyl-quinoline

(2-(4-methoxyphenyl)-6-methylquinoline)

1-benzyl-6-methyl-quinolinium; chloride