Methyl cis-3-(Boc-aMino)c...

Base Information

• Chemical Name: Methyl cis-3-(Boc-aMino)c...
• CAS No.: 142733-63-9
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.27286
• Hs Code.: 2922498590
• Mol file: 142733-63-9.mol

Synonyms:Methyl cis-3-(Boc-aMino)c...;Methyl cis-3-(Boc-aMino)cyclobutanecarboxylate;cis-Methyl 3-(tert-butoxycarbonylamino)cyclobutanecarboxylate

Chemical Property of Methyl cis-3-(Boc-aMino)c...

Chemical Property:

• Boiling Point: 314.1±31.0 °C(Predicted)
• PKA: 12.05±0.40(Predicted)
• PSA: 68.12000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 1.66710
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

METHYL CIS-3-(BOC-AMINO)CYCLOBUTANECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl cis-3-(Boc-aMino)c...

There total 3 articles about Methyl cis-3-(Boc-aMino)c... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cis-methyl 3-carboxamidocyclobutanecarboxylate (142733-62-8) + tert-butyl alcohol (75-65-0) → cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate (142733-63-9,1101173-77-6)

Guidance literature:

With lead(IV) acetate; In N,N-dimethyl-formamide; for 0.333333h; Heating;

Reference yield:

cis-1,3-cyclobutanedicarboxylic acid monomethyl ester (142733-61-7,116569-00-7,1401103-71-6) → cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate (142733-63-9,1101173-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0.5 h / 0 °C

2: NH₃ / CH₂Cl₂ / 3 h / 0 °C

3: 98 percent / Pb(OAc)4 / dimethylformamide / 0.33 h / Heating

With lead(IV) acetate; ammonia; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

3-Ethoxycarbonyloxycarbonyl-cyclobutanecarboxylic acid methyl ester → cis-methyl 3-<(t-butoxycarbonyl)amino>cyclobutanecarboxylate (142733-63-9,1101173-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / Pb(OAc)4 / dimethylformamide / 0.33 h / Heating

With lead(IV) acetate; ammonia; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

cis-methyl 3-carboxamidocyclobutanecarboxylate

tert-butyl alcohol

cis-1,3-cyclobutanedicarboxylic acid monomethyl ester

Downstream raw materials:

cis-3-hydroxymethyl-1-<(t-butoxycarbonyl)amino>cyclobutane

cis-(3-aminocyclobutyl)methanol hydrochloride

cis-3-amino-1-cyclobutanemethanol

tert-butyl N-(cis-3-formylcyclobutyl)carbamate