4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL

Base Information

• Chemical Name: 4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL
• CAS No.: 361382-26-5
• Molecular Formula: C16H23NO2
• Molecular Weight: 261.364
• Mol file: 361382-26-5.mol

Synonyms:4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL;4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANO;2-[4-[1-(4,4-diMethyl-5H-oxazol-2-yl)-1-Methyl-ethyl]phenyl]ethanol;2-(4-(2-(4,4-diMethyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phenyl)ethanol;Bilastine Intermediate 2;2-(4-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phenyl)ethan-1-ol

Chemical Property of 4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL

Chemical Property:

• Vapor Pressure: 3.08E-06mmHg at 25°C
• Boiling Point: 373.4°C at 760 mmHg
• PKA: 14.88±0.10(Predicted)
• Flash Point: 179.6°C
• PSA: 41.82000
• Density: 1.05g/cm³
• LogP: 2.14190

Purity/Quality:

99%, ^*data from raw suppliers

2-[4-[2-(4,4-dimethyl-5H-1,3-oxazol-2-yl)propan-2-yl]phenyl]ethanol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL

There total 1 articles about 4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester (1181267-31-1) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-{1-[4-(2-hydroxyethyl)phenyl]-1-methylethyl}-4,5-2H-4,4-dimethyl-oxazole (361382-26-5)

Guidance literature:

With potassium tert-butylate; In dichloromethane;

Reference yield: 90.0%

2-{1-[4-(2-hydroxyethyl)phenyl]-1-methylethyl}-4,5-2H-4,4-dimethyl-oxazole (361382-26-5) + p-toluenesulfonyl chloride (98-59-9) → 2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl p-toluenesulfonate (202189-76-2)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; at 5 ℃; Reagent/catalyst;

Reference yield: 80.1%

2-{1-[4-(2-hydroxyethyl)phenyl]-1-methylethyl}-4,5-2H-4,4-dimethyl-oxazole (361382-26-5) → 2-{2-[4-(2-chloroethyl)phenyl]propyl}-4,5-dihydro-4,4-dimethyloxazole (1181267-35-5)

Guidance literature:

With thionyl chloride; In chloroform; for 1h; Solvent;

upstream raw materials:

2-methyl-2-(4-(2-hydroxyethyl)phenyl)propionic acid ethyl ester

2-Amino-2-methyl-1-propanol

Downstream raw materials:

2-{2-[4-(2-chloroethyl)phenyl]propyl}-4,5-dihydro-4,4-dimethyloxazole

2-(2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)propan-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

Bilastine

2-{4-[1-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-1-methylethyl]phenyl}ethyl p-toluenesulfonate

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