Leucine orlistat, (-)-

Base Information Edit

Chemical Name:Leucine orlistat, (-)-
CAS No.:104872-28-8
Molecular Formula:C₂₉H₅₃NO₅
Molecular Weight:495.744
Hs Code.:
UNII:7QMQ98VHOQ
ChEMBL ID:CHEMBL458622
DSSTox Substance ID:DTXSID50146801
Nikkaji Number:J3.336.564K
Mol file:104872-28-8.mol

Synonyms:Leucine orlistat, (-)-;104872-28-8;D-Leucine orlistat;(R,S,S,S)-Orlistat;Leucine orlistat, D-;UNII-7QMQ98VHOQ;7QMQ98VHOQ;CHEMBL458622;Orlistat impurity, D-leucine orlistat- [USP];[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2R)-2-formamido-4-methylpentanoate;D-Leucine, N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester;N-Formyl-D-leucine (S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester;(-)-leucine orlistat;Orlistat, (R,S,S,S)-;Orlistat (R,S,S,S)-Isomer;SCHEMBL10926856;DTXSID50146801;BDBM50274723;D-LEUCINE ORLISTAT [USP IMPURITY];EN300-19655482;Q27268718;N-Formyl-D-leucine-(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester;(2S)-1-[(2S,3S)-3-HEXYL-4-OXOOXETAN-2-YL]TRIDECAN-2-YL (2R)-2-FORMAMIDO-4-METHYLPENTANOATE

Suppliers and Price of Leucine orlistat, (-)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R,S,S,S)-Orlistat
10mg
$ 8170.00

Medical Isotopes, Inc.
N-Formyl-D-leucine(1S)-1-[[(2S-3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecylester
2 mg
$ 1456.00

American Custom Chemicals Corporation
ORLISTAT-D3 95.00%
5MG
$ 502.78

Total 8 raw suppliers

Chemical Property of Leucine orlistat, (-)- Edit

Chemical Property:

PSA：85.19000
LogP:7.72220
Storage Temp.:-20°C Freezer
Solubility.:Chloroform (Sparingly), Methanol (Slightly)
XLogP3:10
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:23
Exact Mass:495.39237379
Heavy Atom Count:35
Complexity:579

Purity/Quality:

99% ^*data from raw suppliers

(R,S,S,S)-Orlistat ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O
Isomeric SMILES:CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O
Uses An isomeric impurity of Orlistat (O686500) with modulatory activity on endocannabinoid 2-arachidonoylglycerol metabolism.

Technology Process of Leucine orlistat, (-)-

There total 241 articles about Leucine orlistat, (-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 96829-59-3
(-)-lipstatin

: 104872-04-0,104872-27-7,104872-28-8,111466-61-6,111466-62-7,111466-63-8,130193-40-7,130193-41-8,130193-42-9,130193-43-0,96829-58-2,1225451-00-2
Orlistat

Guidance literature:: With sodium tetrahydroborate; (R,R)-(-)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine cobalt; copper(l) chloride; In acetonitrile; at 15 ℃; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield: 94.0%

: 5338-45-4,44978-39-4,89921-44-8,6113-61-7
N-formyl-L-leucine

: 68711-40-0,104871-99-0,104872-00-6,104872-03-9,104872-05-1,104872-07-3,104872-19-7,104872-06-2
(3S,4S)-3-hexyl-4-[(R)-2-hydroxytridecyl]-2-oxetanone

: 104872-04-0,104872-27-7,104872-28-8,111466-61-6,111466-62-7,111466-63-8,130193-40-7,130193-41-8,130193-42-9,130193-43-0,96829-58-2,1225451-00-2
Orlistat

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/0l1002913