Val-cit-PAB-OH

Base Information

Chemical Name:Val-cit-PAB-OH
CAS No.:159857-79-1
Molecular Formula:C18H29N5O4
Molecular Weight:379.459
Hs Code.:
Mol file:159857-79-1.mol

Synonyms:Val-cit-PAB-OH;L-Valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide;(S)-2-((R)-2-amino-3-methylbutanamido)-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide

Suppliers and Price of Val-cit-PAB-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Val-cit-PAB-OH
100mg
$ 580.00

TCI Chemical
Val-Cit-PAB-OH
25MG
$ 165.00

TCI Chemical
Val-Cit-PAB-OH
100MG
$ 495.00

DC Chemicals
Val-cit-PAB-OH >97%
1 g
$ 1200.00

Crysdot
Val-Cit-PAB-OH 98+%
100mg
$ 216.00

ChemScene
Val-cit-PAB-OH 99.35%
250mg
$ 157.00

ChemScene
Val-cit-PAB-OH 99.35%
100mg
$ 87.00

ChemScene
Val-cit-PAB-OH 99.35%
1g
$ 341.00

Chemenu
Val-Cit-PAB-OH 95+%
1g
$ 729.00

BroadPharm
Val-Cit-PAB-OH 95%
1 G
$ 450.00

Total 58 raw suppliers

Chemical Property of Val-cit-PAB-OH

Chemical Property:

Melting Point:168 °C(dec.)
Boiling Point:715.0±60.0 °C(Predicted)
PKA:13.75±0.46(Predicted)
PSA：159.57000
Density:1.243±0.06 g/cm3(Predicted)
LogP:2.28940
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

Val-cit-PAB-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.
Uses Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.

Technology Process of Val-cit-PAB-OH

There total 28 articles about Val-cit-PAB-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 870487-04-0
(S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate

: 86060-87-9
Fmoc-Val-OPfp

: 159857-79-1
(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide

Guidance literature:: (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate; With piperidine; In N,N-dimethyl-formamide; at 23 ℃; for 3h;

Fmoc-Val-OPfp; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 23 ℃; for 24h;

With piperidine; In N,N-dimethyl-formamide; at 23 ℃; for 1h;

Reference yield:

: 870487-09-5
tert-butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentane-2-yl)amino)-3-methyl-1-oxobutane-2-yl)carbamate

: 159857-79-1
(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-N-[4-(hydroxymethyl)phenyl]-5-ureidopentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 20 °C

2: sodium hydroxide; water / 1,4-dioxane / 3 h / 20 °C

With water; sodium hydroxide; In 1,4-dioxane; dichloromethane;