(S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate

Base Information

• Chemical Name: (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate
• CAS No.: 870487-04-0
• Molecular Formula: C₂₈H₃₀N₄O₅
• Molecular Weight: 502.57
• Mol file: 870487-04-0.mol

Synonyms:(S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate

Chemical Property of (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate

There total 4 articles about (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-aminobenzenemethanol (623-04-1) + (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid (133174-15-9) → (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate (870487-04-0)

Guidance literature:

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -40 ℃; for 3h; Inert atmosphere;

4-aminobenzenemethanol; With 4-methyl-morpholine; In tetrahydrofuran; at -40 - 23 ℃; for 21h; Inert atmosphere;

Reference yield:

Citrulline (372-75-8) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate (870487-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane; water / 2 h / 0 - 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane; methanol / 16 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

Citrulline (372-75-8) → (S)-(9H-fluoren-9-yl)methyl (1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)carbamate (870487-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / water; 1,4-dioxane / 2 h / 0 - 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / methanol; dichloromethane / 16 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

4-aminobenzenemethanol

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid

Citrulline

(fluorenylmethoxy)carbonyl chloride

Downstream raw materials:

Fmoc-Cit-PABC-PNP

(S)-2-amino-N-(4-(hydroxymethyl)phenyl)-5-ureidopentanamide

C₂₂H₃₃N₅O₆

C₅₀H₆₀N₆O₁₈