1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide

Base Information

• Chemical Name: 1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide
• CAS No.: 916176-51-7
• Molecular Formula: C7H5ClN2O
• Molecular Weight: 168.583
• Hs Code.: 2933990090
• Mol file: 916176-51-7.mol

Synonyms:1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide;5-Chloro-7-oxide-7-azaindole

Chemical Property of 1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide

Chemical Property:

• PSA: 41.25000
• Density: 1.52
• LogP: 2.24980

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-7-oxide-7-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide

There total 1 articles about 1H-pyrrolo[2,3-b]pyridine, 5-chloro-, 7-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8) → 5-chloro-1H-pyrrolo[2.3-b]pyridine oxide (916176-51-7) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In ethyl acetate; at 0 - 20 ℃; for 35h;

Reference yield: 84.9%

5-chloro-1H-pyrrolo[2.3-b]pyridine oxide (916176-51-7) → 4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine (916176-52-8)

Guidance literature:

With trifluoromethylsulfonic anhydride; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

5-chloro-1H-pyrrolo[2.3-b]pyridine oxide (916176-51-7) → 4-bromo-5-chloro-1-p-toluenesulfonyl-1H-pyrrolo[2,3-b]pyridine (916176-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetramethylammonium bromide; Methanesulfonic anhydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

1.2: pH 7

2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

With tetramethylammonium bromide; sodium hydride; Methanesulfonic anhydride; In N,N-dimethyl-formamide;

upstream raw materials:

5-chloro-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

4-bromo-5-chloro-1-p-toluenesulfonyl-1H-pyrrolo[2,3-b]pyridine

Refernces