6-(4-Chlorophenyl)-picolinic acid

Base Information

• Chemical Name: 6-(4-Chlorophenyl)-picolinic acid
• CAS No.: 135432-77-8
• Molecular Formula: C12H8ClNO2
• Molecular Weight: 233.654
• Hs Code.: 2933399090
• Mol file: 135432-77-8.mol

Synonyms:6-(4-Chlorophenyl)-picolinic acid;6-(4-chlorophenyl)-2-Pyridinecarboxylic acid

Chemical Property of 6-(4-Chlorophenyl)-picolinic acid

Chemical Property:

• Boiling Point: 433.5±35.0 °C(Predicted)
• PKA: 4.49±0.25(Predicted)
• PSA: 50.19000
• Density: 1.355±0.06 g/cm3(Predicted)
• LogP: 3.10020
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-(4-Chlorophenyl)picolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-(4-Chlorophenyl)picolinic acid

Technology Process of 6-(4-Chlorophenyl)-picolinic acid

There total 8 articles about 6-(4-Chlorophenyl)-picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C13H10ClNO2 → 6-(4-chlorophenyl)-2-pyridinecarboxylic acid (135432-77-8)

Guidance literature:

With sodium hydroxide; In methanol; at 65 ℃;

DOI:10.1021/acs.jafc.6b00675

Reference yield: 78.0%

→ 6-(4-chlorophenyl)-2-pyridinecarboxylic acid (135432-77-8)

Guidance literature:

Reference yield: 72.0%

6-bromo-pyridine-2-carboxylic acid (21190-87-4) + 4-Chlorophenylboronic acid (1679-18-1) → 6-(4-chlorophenyl)-2-pyridinecarboxylic acid (135432-77-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; for 24h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1246/bcsj.20190134

upstream raw materials:

6-bromo-pyridine-2-carboxylic acid

methyl 6-Bromopicolinate

4-Chlorophenylboronic acid

6-chloropyridine-2-carboxylic acid ethyl ester

Refernces

• 1、 Tanaka, Shinji,Suzuki, Yusuke,Kimura, Takahiro,Kitamura, Masato. "A chiral picolinic acid ligand, Cl-NAPH-PyCOOH, for CPRU-catalyzed dehydrative allylation: Design, synthesis, and properties". . p. 1707 - 1720. Retrieved 2019/10/01.
• 2、 -. "EP2 RECEPTOR AGONISTS". Page/Page column 193. . Retrieved 2008/06/13.