Enviroxime

Base Information

• Chemical Name: Enviroxime
• CAS No.: 72301-79-2
• Molecular Formula: C₁₇H₁₈N₄O₃S
• Molecular Weight: 358.421
• NSC Number: 346230
• UNII: 133013L556
• DSSTox Substance ID: DTXSID40222628
• Nikkaji Number: J34.294G
• Wikidata: Q27273110
• NCI Thesaurus Code: C83691,C152898
• ChEMBL ID: CHEMBL283403
• Mol file: 72301-79-2.mol

Synonyms:(E)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime;(Z)-2-Amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime;2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenyl ketone oxime;2-amino-6-benzoyl-1-(isopropylsulfonyl)benzimidazole oxime;6-(((hydroxyimino)phenyl)methyl)-1-((1-methylethyl)sulfonyl)-1H-benzimidazol-2-amine;AR 336;AR-336;enviroxime;Lilly 122771-72;Lilly 122772;LY 122771-72;LY 122772;viroxime;zinviroxime

Chemical Property of Enviroxime

Chemical Property:

• Vapor Pressure: 1.35E-15mmHg at 25°C
• Melting Point: 198-199°
• Boiling Point: 607.2°C at 760 mmHg
• Flash Point: 321°C
• PSA: 118.95000
• Density: 1.41g/cm³
• LogP: 4.09340
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 358.10996162
• Heavy Atom Count: 25
• Complexity: 596

Purity/Quality:

99%, ^*data from raw suppliers

Enviroxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)S(=O)(=O)N1C2=C(C=CC(=C2)C(=NO)C3=CC=CC=C3)N=C1N
• Isomeric SMILES: CC(C)S(=O)(=O)N1C2=C(C=CC(=C2)/C(=N/O)/C3=CC=CC=C3)N=C1N
• Description: Enviroxime is an antiviral agent. It inhibits coxsackievirus B3-, rhinovirus-, or poliovirus-induced plaque formation in HeLa monolayer cell cultures when used at concentrations of 0.1, 1, and 10 μg/ml. Enviroxime (1 μg/ml) inhibits production of poliovirus PV1 viral RNA in HeLa monolayer cell cultures. It reduces viral titers in DRAW macrophages infected with the DA strain of Theiler''s murine encephalomyelitis virus.
• Uses: Enviroxime
• Therapeutic Function: Antiviral

Technology Process of Enviroxime

There total 2 articles about Enviroxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ enviroxime (63198-97-0,72301-78-1,72301-79-2)

Guidance literature:

Reference yield:

1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole (63197-61-5) → syn-6-<<(hydroxyimino)phenyl>methyl>-1-<(1-methylethyl)sulfonyl>-1H-benzimidazol-2-amine (72301-78-1) + enviroxime (63198-97-0,72301-78-1,72301-79-2)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 24h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jm00178a004

upstream raw materials:

1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole

Refernces

• 1、 -. "Separation of syn and anti oximes of 1-sulfonyl-2-aminobenzimidazoles". . . Retrieved 2008/06/13.