Technology Process of 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester
There total 4 articles about 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; palladium on activated charcoal; hydrogen / ethanol / 4 h
2: dmap; triethylamine / ethanol / 0.5 h
With
dmap; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: silver nitrate; N-iodo-succinimide / N,N-dimethyl-formamide / 0.5 h / Cooling with ice
2: potassium tert-butylate; 18-crown-6 ether / 1-methyl-pyrrolidin-2-one / 0.07 h / 60 °C
3: potassium carbonate; palladium on activated charcoal; hydrogen / ethanol / 4 h
4: dmap; triethylamine / ethanol / 0.5 h
With
dmap; N-iodo-succinimide; 18-crown-6 ether; palladium on activated charcoal; potassium tert-butylate; hydrogen; potassium carbonate; silver nitrate; triethylamine;
In
1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;