tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate
CAS No.:1194537-67-1
Molecular Formula:C₂₈H₃₀F₂N₆O₂
Molecular Weight:520.582
Hs Code.:

Synonyms:tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

There total 8 articles about tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 909562-68-1
2-chloro-7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidine

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 1194537-67-1
tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.08.021

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1194537-67-1
tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / ethanol / 0.5 h

2: palladium on activated charcoal; hydrogen; triethylamine / ethanol

3: trifluoroacetic acid / dichloromethane / 3 h

4: potassium carbonate / dimethyl sulfoxide / 2 h / 60 °C

5: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / 1,4-dioxane / 3 h / 80 °C

With dmap; palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1393648-54-8
tert-butyl 2-chloropyrrolo[2,3-d]pyrimidine-7-carboxylate

: 1194537-67-1
tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: potassium carbonate / dimethyl sulfoxide / 2 h / 60 °C

3: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / 1,4-dioxane / 3 h / 80 °C

With palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;