7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[(3,5-difluorophenyl)methyl]-N-[4-(1-piperazinyl)phenyl]-

Base Information

Chemical Name:7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[(3,5-difluorophenyl)methyl]-N-[4-(1-piperazinyl)phenyl]-
CAS No.:909564-40-5
Molecular Formula:C23H22F2N6
Molecular Weight:420.465
Hs Code.:

Synonyms:

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Chemical Property of 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[(3,5-difluorophenyl)methyl]-N-[4-(1-piperazinyl)phenyl]-

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Technology Process of 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[(3,5-difluorophenyl)methyl]-N-[4-(1-piperazinyl)phenyl]-

There total 9 articles about 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[(3,5-difluorophenyl)methyl]-N-[4-(1-piperazinyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194537-67-1
tert-butyl 4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

: 909564-40-5
7-(3,5-difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate; at 80 ℃; for 13h;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 909564-40-5
7-(3,5-difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; triethylamine / ethanol / 0.5 h

2: palladium on activated charcoal; hydrogen; triethylamine / ethanol

3: trifluoroacetic acid / dichloromethane / 3 h

4: potassium carbonate / dimethyl sulfoxide / 2 h / 60 °C

5: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / 1,4-dioxane / 3 h / 80 °C

6: hydrogenchloride / water; methanol; tetrahydrofuran; ethyl acetate / 13 h / 80 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1393648-54-8
tert-butyl 2-chloropyrrolo[2,3-d]pyrimidine-7-carboxylate

: 909564-40-5
7-(3,5-difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: potassium carbonate / dimethyl sulfoxide / 2 h / 60 °C

3: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / 1,4-dioxane / 3 h / 80 °C

4: hydrogenchloride / water; methanol; tetrahydrofuran; ethyl acetate / 13 h / 80 °C

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;