4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde

Base Information

• Chemical Name: 4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde
• CAS No.: 1322091-24-6
• Molecular Formula: C16H11FO2
• Molecular Weight: 254.261
• Mol file: 1322091-24-6.mol

Synonyms:4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde

Chemical Property of 4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 3.04660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde

There total 1 articles about 4-fluoro-2-((4-Methoxyphenyl)ethynyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-bromo-4-fluorobenzaldehyde (59142-68-6) + 4-methoxyphenylacetylen (768-60-5) → 4-fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde (1322091-24-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃;

DOI:10.1002/chem.201501725

Reference yield: 85.0%

dimethyl 1,1-cyclopropanedicarboxylate (6914-71-2,151444-20-1) + 4-fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde (1322091-24-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate (1338721-76-8)

Guidance literature:

With nickel(II) perchlorate hexahydrate; silver trifluoromethanesulfonate; In 1,4-dioxane; at 50 ℃; Inert atmosphere; Molecular sieve;

DOI:10.1055/s-0030-1260063

Reference yield: 51.0%

p-bromophenylsulfonyl hydrazide (2297-64-5) + 4-fluoro-2-((4-methoxyphenyl)ethynyl)benzaldehyde (1322091-24-6) → 3-((4-bromophenyl)sulfonyl)-1-diazo-5-fluoro-2-(4-methoxyphenyl)-1H-indene

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In nonane; dimethyl sulfoxide; acetonitrile; at 70 ℃; for 2.5h; regioselective reaction; Molecular sieve;

DOI:10.1021/acs.orglett.6b00655

upstream raw materials:

2-bromo-4-fluorobenzaldehyde

4-methoxyphenylacetylen

Downstream raw materials:

dimethyl 9-fluoro-6-(4-methoxyphenyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate

1,3-dicyclohexyl-1-(6-fluoro-3-(4-methoxyphenyl)isoquinolin-1-yl)-2-tosylguanidine

Refernces

• 1、 Guo, Jia,Peng, Xiaoshi,Wang, Xiaoyu,Xie, Fukai,Zhang, Xinhang,Liang, Guoduan,Sun, Zenghui,Liu, Yongxiang,Cheng, Maosheng,Liu, Yang. "A gold-catalyzed cycloisomerization/aerobic oxidation cascade strategy for 2-aryl indenones from 1,5-enynes". supporting information. p. 9147 - 9151. Retrieved 2019/01/03.