(1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol

Base Information

Chemical Name:(1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol
CAS No.:1233193-58-2
Molecular Formula:C42H44O3Si
Molecular Weight:624.895
Hs Code.:
Mol file:1233193-58-2.mol

Synonyms:(1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol;(1R,3R,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-methylene-3-trityloxymethyl-cyclopentanol

Suppliers and Price of (1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 12 raw suppliers

Chemical Property of (1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol

Chemical Property:

Boiling Point:668.4±55.0 °C(Predicted)
PKA:13.85±0.60(Predicted)
PSA：38.69000
Density:1.14±0.1 g/cm3(Predicted)
LogP:7.87730

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol

There total 8 articles about (1R,3R,4S)-4-(tert-butyldiphenylsilyloxy)-2-Methylene-3-(trityloxyMethyl)cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: nysted reagent

: 1233193-55-9
3-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-2-trityloxymethyl-cyclopentanone

: 1233193-58-2
(1R,3R,4S)-4-tert-butyldiphenylsilyloxy-3-(trityloxymethyl)-2-methylene-1-cyclopentanol

Guidance literature:: With titanium tetrachloride; In tetrahydrofuran; at -40 - 20 ℃;

Reference yield:

: 1233193-52-6
2-((trityloxy)methyl)cyclopent-2-en-1-one

: 1233193-58-2
(1R,3R,4S)-4-tert-butyldiphenylsilyloxy-3-(trityloxymethyl)-2-methylene-1-cyclopentanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-dimethyl sulfide complex / (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / dichloromethane / 3 h / 0 °C

2.1: 1H-imidazole / dichloromethane / 2 h / 20 °C

3.1: L-diisopinocampheylborane / tetrahydrofuran / 5 h / 0 - 20 °C

3.2: 1.75 h / 0 - 12 °C

4.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

6.1: 3-chloro-benzenecarboperoxoic acid; disodium hydrogenphosphate / dichloromethane / 2.5 h / -25 °C

6.2: -25 - 20 °C

7.1: titanium tetrachloride / tetrahydrofuran / 3.5 h / -40 - 20 °C

With 1H-imidazole; disodium hydrogenphosphate; borane-dimethyl sulfide complex; titanium tetrachloride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; L-diisopinocampheylborane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1233193-50-4
3-(tert-butyl-diphenyl-silanyloxy)-2-trityloxymethyl-cyclo-pentanone

: 1233193-58-2
(1R,3R,4S)-4-tert-butyldiphenylsilyloxy-3-(trityloxymethyl)-2-methylene-1-cyclopentanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2.1: 3-chloro-benzenecarboperoxoic acid; disodium hydrogenphosphate / dichloromethane / 2.5 h / -25 °C

2.2: -25 - 20 °C

3.1: titanium tetrachloride / tetrahydrofuran / 3.5 h / -40 - 20 °C

With disodium hydrogenphosphate; titanium tetrachloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;