5-Iodonaphthalen-2-ol

Base Information

• Chemical Name: 5-Iodonaphthalen-2-ol
• CAS No.: 128542-54-1
• Molecular Formula: C10H7IO
• Molecular Weight: 270.069
• European Community (EC) Number: 825-442-9
• DSSTox Substance ID: DTXSID00595527
• Nikkaji Number: J1.537.069F
• Wikidata: Q82490543
• Mol file: 128542-54-1.mol

Synonyms:5-iodonaphthalen-2-ol;128542-54-1;1-Iodo-6-naphthol;6-Hydroxy-1-iodonaphthalene;5-iodo-2-naphthol;SCHEMBL7232768;DTXSID00595527;CVEDCNVEFNTPDU-UHFFFAOYSA-N;AT31046;DB-083957;EN300-2010502

Chemical Property of 5-Iodonaphthalen-2-ol

Chemical Property:

• PSA: 20.23000
• LogP: 3.15000
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 269.95416
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=C2)O)C(=C1)I

Technology Process of 5-Iodonaphthalen-2-ol

There total 1 articles about 5-Iodonaphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

5-amino-2-naphthol (86-97-5) → 1-iodo-6-hydroxynaphthalene (128542-54-1)

Guidance literature:

5-amino-2-naphthol; With sulfuric acid; acetic acid; sodium nitrite; In water; at 0 - 20 ℃; for 1h;

With urea; potassium iodide; In water; at 0 - 20 ℃; for 24h;

Reference yield: 72.0%

10-phenylanthracene-9-boronic acid (334658-75-2) + 1-iodo-6-hydroxynaphthalene (128542-54-1) → C30H20O

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; toluene; at 110 ℃;

Reference yield:

1-iodo-6-hydroxynaphthalene (128542-54-1) + (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester (350584-51-9) → {4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(6-hydroxy-naphthalen-1-yl)-prop-2-ynylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0960-894X(01)00173-1

upstream raw materials:

5-amino-2-naphthol