Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride

Base Information

• Chemical Name: Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride
• CAS No.: 51098-46-5
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Hs Code.: 2933990090
• Mol file: 51098-46-5.mol

Synonyms:Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride;2-Methyl-DL-proline methyl ester HCl

Chemical Property of Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.43230

Purity/Quality:

97% ^*data from raw suppliers

methyl2-methylpyrrolidine-2-carboxylatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride

There total 10 articles about Methyl 2-methylpyrrolidine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2-methylpyrrolidine-2-carboxylic acid (42856-71-3) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 100.0%

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (220200-88-4) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 0.333333h; Heating / reflux;

Reference yield: 100.0%

methanol (67-56-1) + (3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one (220200-88-4) → methyl (S)-2-methylpyrrolidine-2-carboxylate monohydrochloride (220060-08-2,51098-46-5,1286768-32-8)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1016/j.tet.2005.08.026

upstream raw materials:

methanol

(3R,7aS)-7a-methyl-3-(trichloromethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one

(S)-2-methylpyrrolidine-2-carboxylic acid

(2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one

Downstream raw materials:

glycyl-L-2-methylprolyl-L-glutamic acid

(8aS)-8a-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

(R)-methyl 11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate

(R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate