6969-71-7Relevant articles and documents
Preparation method of pyridine triazolone
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Paragraph 0014; 0019-0021, (2020/12/30)
The invention discloses a preparation method of pyridine triazolone. The method comprises the following steps: 1) adding 2-chloropyridine and hydrazine hydrate into a first reaction flask, stirring, heating to 90-110 DEG C, and keeping the temperature to react for 6-8 hours to obtain a first mixed solution; 2) adding the first mixed solution into a second reaction bottle, extracting, recovering hydrazine hydrate under reduced pressure, cooling and adjusting alkali, and performing secondary extraction to obtain 2-pyridine hydrazine; 3) adding the 2-pyridylhydrazine and urea into the reaction kettle, heating to 150-160 DEG C, carrying out heat preservation reaction for 3-4 hours, cooling, adding water for dissolving, cooling, carrying out stirring reacting for 1 hour, and performing suctionfiltration, washing and drying on the reaction system to obtain a crude product; and 4) adding the crude product and DMSO into a third reaction flask, heating, stirring, filtering, cooling, carrying out heat preservation reaction for 1-2 hours, filtering, and drying to obtain pyridinetriazolone. The preparation method of pyridinetriazolone provided by the invention has the advantages that the total yield can reach 70% or above, and the purity of the obtained product can reach 99.2% or above.
TRIAZOLONES DERIVATIVES FOR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE
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, (2017/04/18)
The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, codrug, cocrystal, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
Microwave-assisted N-debenzylation of amides with triflic acid
Rombouts, Frederik,Franken, Dennis,Martínez-Lamenca, Carolina,Braeken, Mirielle,Zavattaro, Chiara,Chen, Jinsheng,Trabanco, Andrés A.
experimental part, p. 4815 - 4818 (2010/10/02)
A new and facile microwave-assisted protocol for the debenzylation of N-benzylamides with triflic acid has been developed. Both secondary and tertiary aliphatic or aromatic amides are obtained in moderate to good yields.