MYCOPHENOLATE METHYL ESTER

Base Information

• Chemical Name: MYCOPHENOLATE METHYL ESTER
• CAS No.: 24243-40-1
• Molecular Formula: C18H22O6
• Molecular Weight: 334.369
• Mol file: 24243-40-1.mol

Synonyms:MYCOPHENOLATE METHYL ESTER;6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-1,3-DIHYDRO-ISOBENZOFURAN-5-YL)-4-METHYL-HEX-4-ENOIC ACID METHYL ESTER

Chemical Property of MYCOPHENOLATE METHYL ESTER

Chemical Property:

• PSA: 82.06000
• LogP: 2.82160

Purity/Quality:

97% ^*data from raw suppliers

MYCOPHENOLATE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MYCOPHENOLATE METHYL ESTER

There total 8 articles about MYCOPHENOLATE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + mycophenolic acid (24280-93-1) → 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enoic acid methyl ester (24243-40-1)

Guidance literature:

With thionyl chloride; at 0 - 70 ℃;

Reference yield:

5-bromo-7-hydroxy-4-methylisobenzofuran-1,3-dione → 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enoic acid methyl ester (24243-40-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0 - 20 °C

2: copper(I) bromide / ethyl acetate; toluene / 20 - 80 °C

3: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

With methanol; sodium tetrahydroborate; N-iodo-succinimide; copper(I) bromide; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene; 4: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);

Reference yield:

5-bromo-7-hydroxy-4-methylisobenzofuran-1(3H)-one → 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-isobenzofuran-5-yl)-4-methyl-hex-4-enoic acid methyl ester (24243-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(I) bromide / ethyl acetate; toluene / 20 - 80 °C

2: N-iodo-succinimide / N,N-dimethyl-formamide / 20 °C

With N-iodo-succinimide; copper(I) bromide; In ethyl acetate; N,N-dimethyl-formamide; toluene; 3: |Stille Cross-Coupling (Migita-Kosugi-Stille Coupling);

upstream raw materials:

methanol

mycophenolic acid

7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one

7-hydroxy-6-iodo-5-methoxy-4-methylisobenzofuran-1(3H)-one

Downstream raw materials:

mycophenolic acid