Technology Process of CiMbuterol-D9
There total 6 articles about CiMbuterol-D9 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 6 h / 160 °C / Inert atmosphere
2: copper(ll) bromide / tetrahydrofuran / 2 h / 70 °C
3: ethanol / 2.5 h / 0 - 60 °C / Inert atmosphere
4: sodium tetrahydroborate / ethanol / 4 h / 20 °C
With
sodium tetrahydroborate; copper(ll) bromide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.3446
- Guidance literature:
-
1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-amine; 3-cyano-4-aminophenyl bromomethyl ketone;
With
tetrabutylammomium bromide;
In
ethanol;
at 70 ℃;
for 4h;
With
sodium tetrahydroborate;
In
ethanol;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / toluene / 0.17 h / 35 °C
2: N,N-dimethyl-formamide / 6 h / 160 °C / Inert atmosphere
3: copper(ll) bromide / tetrahydrofuran / 2 h / 70 °C
4: ethanol / 2.5 h / 0 - 60 °C / Inert atmosphere
5: sodium tetrahydroborate / ethanol / 4 h / 20 °C
With
sodium tetrahydroborate; N-Bromosuccinimide; copper(ll) bromide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jlcr.3446
